BACKGROUND: The usage of platelet glycoprotein (GP) IIb/IIIa receptor inhibitors improves the outcome during high-risk percutaneous coronary interventions (PCI). The aim of this study was to evaluate the long-term effects after a planned switch from abciximab to eptifibatide during PCI. HYPOTHESIS: A switch from the general use of abciximab to eptifibatide as a GP IIb/IIIa in connection with PCI would not have any negative effects on long-term clinical outcomes. METHODS: To reduce costs, a general switch from abciximab to eptifibatide was instituted in 2004 in 2 university hospitals in Sweden. All patients treated 6 months before and 6 months after the switch were followed for 30 months. During the study period, 1038 patients underwent PCI and received a GP IIb/IIIa receptor inhibitor, 481 (46%) before the switch (Group A) and 557 (54%) after the switch (Group B). The 2 groups had similar baseline characteristics. The primary endpoint was the composite of death, myocardial infarction, stroke, or new coronary revascularization (percutaneous or surgical); secondary endpoints were the individual components of this composite. A separate analysis was performed on patients treated for ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction/unstable angina, and diabetes, respectively. Data were collected from the Swedish Coronary Angiography and Angioplasty Registry. RESULTS: There were no differences between the groups in the primary endpoint (29.7% in Group A vs 29.3% in Group B; P = 0.48) or in any of the secondary endpoints. CONCLUSIONS: A switch from the general usage of abciximab to eptifibatide as a GP IIb/IIIa receptor inhibitor in connection with PCI did not seem to have any negative effects on long-term clinical outcomes.
BACKGROUND: The usage of platelet glycoprotein (GP) IIb/IIIa receptor inhibitors improves the outcome during high-risk percutaneous coronary interventions (PCI). The aim of this study was to evaluate the long-term effects after a planned switch from abciximab to eptifibatide during PCI. HYPOTHESIS: A switch from the general use of abciximab to eptifibatide as a GP IIb/IIIa in connection with PCI would not have any negative effects on long-term clinical outcomes. METHODS: To reduce costs, a general switch from abciximab to eptifibatide was instituted in 2004 in 2 university hospitals in Sweden. All patients treated 6 months before and 6 months after the switch were followed for 30 months. During the study period, 1038 patients underwent PCI and received a GP IIb/IIIa receptor inhibitor, 481 (46%) before the switch (Group A) and 557 (54%) after the switch (Group B). The 2 groups had similar baseline characteristics. The primary endpoint was the composite of death, myocardial infarction, stroke, or new coronary revascularization (percutaneous or surgical); secondary endpoints were the individual components of this composite. A separate analysis was performed on patients treated for ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction/unstable angina, and diabetes, respectively. Data were collected from the Swedish Coronary Angiography and Angioplasty Registry. RESULTS: There were no differences between the groups in the primary endpoint (29.7% in Group A vs 29.3% in Group B; P = 0.48) or in any of the secondary endpoints. CONCLUSIONS: A switch from the general usage of abciximab to eptifibatide as a GP IIb/IIIa receptor inhibitor in connection with PCI did not seem to have any negative effects on long-term clinical outcomes.
Authors: A M Lincoff; R M Califf; D J Moliterno; S G Ellis; J Ducas; J H Kramer; N S Kleiman; E A Cohen; J E Booth; S K Sapp; C F Cabot; E J Topol Journal: N Engl J Med Date: 1999-07-29 Impact factor: 91.245
Authors: Gregg W Stone; Cindy L Grines; David A Cox; Eulogio Garcia; James E Tcheng; John J Griffin; Giulio Guagliumi; Thomas Stuckey; Mark Turco; John D Carroll; Barry D Rutherford; Alexandra J Lansky Journal: N Engl J Med Date: 2002-03-28 Impact factor: 91.245
Authors: E J Topol; D J Moliterno; H C Herrmann; E R Powers; C L Grines; D J Cohen; E A Cohen; M Bertrand; F J Neumann; G W Stone; P M DiBattiste; L Demopoulos Journal: N Engl J Med Date: 2001-06-21 Impact factor: 91.245
Authors: G Montalescot; P Barragan; O Wittenberg; P Ecollan; S Elhadad; P Villain; J M Boulenc; M C Morice; L Maillard; M Pansiéri; R Choussat; P Pinton Journal: N Engl J Med Date: 2001-06-21 Impact factor: 91.245
Authors: J C Blankenship; G Tasissa; J C O'Shea; E A Iliadis; F A Bachour; D J Cohen; H K Lui; T Mann; E Cohen; J E Tcheng Journal: J Am Coll Cardiol Date: 2001-09 Impact factor: 24.094
Authors: J C O'Shea; G E Hafley; S Greenberg; V Hasselblad; T J Lorenz; M M Kitt; J Strony; J E Tcheng Journal: JAMA Date: 2001-05-16 Impact factor: 56.272
Authors: K S Rathod; S Antoniou; P Avari; N Ding; P Wright; C Knight; A K Jain; A Mathur; E J Smith; R Weerackody; A Wragg; D A Jones Journal: JRSM Cardiovasc Dis Date: 2017-10-05