Literature DB >> 21089000

New insights into the biology and pathobiology of beta2-glycoprotein I.

Bill Giannakopoulos1, Peyman Mirarabshahi, Steven A Krilis.   

Abstract

β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms by which anti-β2GPI antibodies in complex with β2GPI may predispose an individual to the antiphospholipid syndrome clinical phenotype. This review examines some of the latest novel findings in this area.

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Year:  2011        PMID： 21089000     DOI： 10.1007/s11926-010-0151-9

Source DB:  PubMed          Journal:  Curr Rheumatol Rep        ISSN： 1523-3774            Impact factor:   4.592


  46 in total

1.  Beta 2 glycoprotein I is a substrate of thiol oxidoreductases.

Authors:  Freda H Passam; Soheila Rahgozar; Miao Qi; Mark J Raftery; Jason W H Wong; Kumiko Tanaka; Yiannis Ioannou; Jing Yun Zhang; Rosalie Gemmell; Jian Chen Qi; Bill Giannakopoulos; Will E Hughes; Philip J Hogg; Steven A Krilis
Journal:  Blood       Date:  2010-09-16       Impact factor: 22.113

2.  Mature dendritic cells readily break tolerance in normal mice but do not lead to disease expression.

Authors:  Maria Georgiev; Lucila M A Agle; Jia Li Chu; Keith B Elkon; Dalit Ashany
Journal:  Arthritis Rheum       Date:  2005-01

3.  Deimination of myelin basic protein. 2. Effect of methylation of MBP on its deimination by peptidylarginine deiminase.

Authors:  L B Pritzker; S Joshi; G Harauz; M A Moscarello
Journal:  Biochemistry       Date:  2000-05-09       Impact factor: 3.162

4.  Immunization with an apoptotic cell-binding protein recapitulates the nephritis and sequential autoantibody emergence of systemic lupus erythematosus.

Authors:  Jerrold S Levine; Rebecca Subang; Samih H Nasr; Sylvie Fournier; Ginette Lajoie; Joan Wither; Joyce Rauch
Journal:  J Immunol       Date:  2006-11-01       Impact factor: 5.422

5.  Oxidized beta2-glycoprotein I induces human dendritic cell maturation and promotes a T helper type 1 response.

Authors:  Brigitta Buttari; Elisabetta Profumo; Vincenzo Mattei; Alessandra Siracusano; Elena Ortona; Paola Margutti; Bruno Salvati; Maurizio Sorice; Rachele Riganò
Journal:  Blood       Date:  2005-08-11       Impact factor: 22.113

6.  Crystal structure of human beta2-glycoprotein I: implications for phospholipid binding and the antiphospholipid syndrome.

Authors:  R Schwarzenbacher; K Zeth; K Diederichs; A Gries; G M Kostner; P Laggner; R Prassl
Journal:  EMBO J       Date:  1999-11-15       Impact factor: 11.598

7.  Impaired thrombin generation in beta 2-glycoprotein I null mice.

Authors:  Y Sheng; S W Reddel; H Herzog; Y X Wang; T Brighton; M P France; S A Robertson; S A Krilis
Journal:  J Biol Chem       Date:  2001-01-05       Impact factor: 5.157

8.  Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus.

Authors:  Philip E Morgan; Allan D Sturgess; Michael J Davies
Journal:  Arthritis Rheum       Date:  2005-07

9.  When the levee doesn't break: a novel role of beta2-glycoprotein I to protect against congenital heart block.

Authors:  Robert M Clancy
Journal:  Arthritis Rheum       Date:  2009-03

10.  Systemic exposure to irradiated apoptotic cells induces autoantibody production.

Authors:  D Mevorach; J L Zhou; X Song; K B Elkon
Journal:  J Exp Med       Date:  1998-07-20       Impact factor: 14.307
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  9 in total

Review 1.  The clinical significance of posttranslational modification of autoantigens.

Authors:  Maria G Zavala-Cerna; Erika A Martínez-García; Olivia Torres-Bugarín; Benjamín Rubio-Jurado; Carlos Riebeling; Arnulfo Nava
Journal:  Clin Rev Allergy Immunol       Date:  2014-08       Impact factor: 8.667

2.  Soluble analog of ApoER2 targeting beta2-glycoprotein I in immune complexes counteracts hypertension in lupus-prone mice with spontaneous antiphospholipid syndrome.

Authors:  A Kolyada; Q Ke; I Karageorgos; P Mahlawat; D A Barrios; P M Kang; N Beglova
Journal:  J Thromb Haemost       Date:  2016-05-03       Impact factor: 5.824

3.  Identification of the binding site for fondaparinux on Beta2-glycoprotein I.

Authors:  Alexey Kolyada; Alfredo De Biasio; Natalia Beglova
Journal:  Biochim Biophys Acta       Date:  2013-06-25

4.  Inhibition of thrombotic properties of persistent autoimmune anti-β2GPI antibodies in the mouse model of antiphospholipid syndrome.

Authors:  Alexey Kolyada; Andrew Porter; Natalia Beglova
Journal:  Blood       Date:  2013-11-25       Impact factor: 22.113

5.  Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome.

Authors:  Fatima El-Assaad; Steven A Krilis; Bill Giannakopoulos
Journal:  Thromb J       Date:  2016-10-04

6.  Βeta 2-glycoprotein I protects mice against gram-negative septicaemia in a sexually dimorphic manner.

Authors:  Fatima El-Assaad; Miao Qi; Alice Kizny Gordon; Jian Qi; Shangwen Dong; Freda Passam; James Crofton Weaver; Bill Giannakopoulos; Steven Anthony Krilis
Journal:  Sci Rep       Date:  2017-08-15       Impact factor: 4.379

7.  In vivo evidence of angiogenesis inhibition by β2-glycoprotein I subfractions in the chorioallantoic membrane of chicken embryos.

Authors:  C M Baldavira; L F Gomes; L T De La Cruz; D A Maria; V L Capelozzi
Journal:  Braz J Med Biol Res       Date:  2021-01-15       Impact factor: 2.590

8.  Significance of K(L/V)WX(I/L/V)P Epitope of the B2Gpi in Its (Patho)Physiologic Function.

Authors:  Urška Žager; Mojca Lunder; Vesna Hodnik; Gregor Anderluh; Saša Čučnik; Tanja Kveder; Borut Božič
Journal:  EJIFCC       Date:  2011-12-22

9.  Association between plasmatic oxidative stress and thrombosis in primary antiphospholipid syndrome.

Authors:  Camila O Vaz; Bruna M Mazetto; Pedro Eduardo N S Vasconcelos; Larissa B Bastos; Maria Aparecida Cursino; Júlia Coelho França Quintanilha; Gabriela Lisiane Tripiquia Vechiatto Mesquita; Ana Paula R Santos; Bruna Cardoso Jacintho; José Diogo Oliveira; Joyce Annichino-Bizzachi; Fernanda A Orsi
Journal:  J Thromb Thrombolysis       Date:  2021-07-05       Impact factor: 2.300
  9 in total

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