| Literature DB >> 21088778 |
Honorius M H F Sanders1, Michele Iafisco, Emilie M Pouget, Paul H H Bomans, Fabio Nudelman, Giuseppe Falini, Gijsbertus de With, Maarten Merkx, Gustav J Strijkers, Klaas Nicolay, Nico A J M Sommerdijk.
Abstract
CryoTEM demonstrates that a CNA35-bearing liposomal MRI contrast agent selectively binds to poorly assembled collagen type I as opposed to well-assembled collagen fibrils, whereas monomeric CNA35 binds to all forms of collagen. It is shown that upon conjugation to liposomes and micelles CNA35 loses its ability to dissociate ordered collagen fibrils and thereby to create its own binding sites.Mesh：
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Year: 2010 PMID： 21088778 DOI： 10.1039/c0cc02901g
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222