| Literature DB >> 21087867 |
Battistina Asproni1, Gabriele Murineddu, Amedeo Pau, Gérard A Pinna, Morten Langgård, Claus Tornby Christoffersen, Jacob Nielsen, Jan Kehler.
Abstract
A series of phenylimidazole-pyrazolo[1,5-c]quinazolines 1a-q was designed, synthesized and characterised as a novel class of potent phophodiesterase 10A (PDE10A) inhibitors. In this series, 2,9-dimethyl-5-(2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl)pyrazolo[1,5-c]quinazoline (1q) showed the highest affinity for PDE10A enzyme (IC(50)=16nM).Entities:
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Year: 2010 PMID： 21087867 DOI： 10.1016/j.bmc.2010.10.038
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641