Literature DB >> 2108674

Involvement of protein kinase C in the regulation of assembly-disassembly of neurofilaments in vitro.

Y Gonda1, K Nishizawa, S Ando, S Kitamura, Y Minoura, Y Nishi, M Inagaki.   

Abstract

Protein kinase C phosphorylated the major mammalian neurofilament protein (NF-L) with approximately 3 mol phosphate per mol protein. The phosphorylated NF-L no longer formed the filaments. Sequential analysis of the tryptic phosphopeptides, together with the known primary sequence, revealed that Ser-12, Ser-27, Ser-33 and Ser-51 were phosphorylated by protein kinase C. These findings contribute toward elucidation of mechanisms regulating the functions of neurofilaments.

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Year:  1990        PMID： 2108674     DOI： 10.1016/0006-291x(90)90667-c

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

Review 1.  Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments.

Authors:  Ram K Sihag; Masaki Inagaki; Tomoya Yamaguchi; Thomas B Shea; Harish C Pant
Journal:  Exp Cell Res       Date:  2007-04-12       Impact factor: 3.905

Review 2.  Implications of intermediate filament protein phosphorylation.

Authors:  N O Ku; J Liao; C F Chou; M B Omary
Journal:  Cancer Metastasis Rev       Date:  1996-12       Impact factor: 9.264

3.  Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M.

Authors:  N D Amin; N G Ahn; H Jaffe; C A Winters; P Grant; H C Pant
Journal:  J Neurosci       Date:  1998-06-01       Impact factor: 6.167

4.  Isolation and characterization of the highly phosphorylated repeat domain of distinct heavy neurofilament subunit (NF-H) isoforms.

Authors:  L Soussan; A Admon; A Aharoni; Y Cohen; D M Michaelson
Journal:  Cell Mol Neurobiol       Date:  1996-08       Impact factor: 5.046

Review 5.  Neurofilaments and Neurofilament Proteins in Health and Disease.

Authors:  Aidong Yuan; Mala V Rao; Ralph A Nixon
Journal:  Cold Spring Harb Perspect Biol       Date:  2017-04-03       Impact factor: 10.005

6.  Phosphorylation of native and reassembled neurofilaments composed of NF-L, NF-M, and NF-H by the catalytic subunit of cAMP-dependent protein kinase.

Authors:  S Hisanaga; Y Matsuoka; K Nishizawa; T Saito; M Inagaki; N Hirokawa
Journal:  Mol Biol Cell       Date:  1994-02       Impact factor: 4.138

7.  Regulation of endogenous and expressed Na+/K+ pumps in Xenopus oocytes by membrane potential and stimulation of protein kinases.

Authors:  L A Vasilets; W Schwarz
Journal:  J Membr Biol       Date:  1992-01       Impact factor: 1.843

8.  Two different protein kinases act on a different time schedule as glial filament kinases during mitosis.

Authors:  Y Matsuoka; K Nishizawa; T Yano; M Shibata; S Ando; T Takahashi; M Inagaki
Journal:  EMBO J       Date:  1992-08       Impact factor: 11.598

9.  Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues.

Authors:  J Liao; L A Lowthert; N O Ku; R Fernandez; M B Omary
Journal:  J Cell Biol       Date:  1995-12       Impact factor: 10.539

10.  PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.

Authors:  M B Omary; G T Baxter; C F Chou; C L Riopel; W Y Lin; B Strulovici
Journal:  J Cell Biol       Date:  1992-05       Impact factor: 10.539
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