OBJECTIVE: To investigate the possible association between the Trp64Arg polymorphism of the β3-adrenergic receptor gene and the homeostasis model assessment of insulin resistance (HOMA-IR) index in schizophrenia patients in Taiwan. METHOD: A total of 203 inpatients who met DSM-IV diagnostic criteria for schizophrenia were recruited from a psychiatry center in Taiwan from September 2002 to August 2003. All patients had been treated with antipsychotics for at least 6 months. The genotyping of the Trp64Arg polymorphism of the β3-adrenergic receptor gene was done by the polymerase chain reaction-restriction fragment length polymorphism method with the restriction enzyme MvaI. The HOMA-IR index was used to indicate the degree of insulin resistance. RESULTS: After adjusting for sex, age, and body mass index status, the association between the HOMA-IR index and the Trp64Arg polymorphism of the β3-adrenergic receptor gene was still positive (regression coefficient = -0.65, P = .033). CONCLUSIONS: The polymorphism of the β3-adrenergic receptor gene may be related to the development of insulin resistance in chronic schizophrenia patients in Taiwan.
OBJECTIVE: To investigate the possible association between the Trp64Arg polymorphism of the β3-adrenergic receptor gene and the homeostasis model assessment of insulin resistance (HOMA-IR) index in schizophreniapatients in Taiwan. METHOD: A total of 203 inpatients who met DSM-IV diagnostic criteria for schizophrenia were recruited from a psychiatry center in Taiwan from September 2002 to August 2003. All patients had been treated with antipsychotics for at least 6 months. The genotyping of the Trp64Arg polymorphism of the β3-adrenergic receptor gene was done by the polymerase chain reaction-restriction fragment length polymorphism method with the restriction enzyme MvaI. The HOMA-IR index was used to indicate the degree of insulin resistance. RESULTS: After adjusting for sex, age, and body mass index status, the association between the HOMA-IR index and the Trp64Arg polymorphism of the β3-adrenergic receptor gene was still positive (regression coefficient = -0.65, P = .033). CONCLUSIONS: The polymorphism of the β3-adrenergic receptor gene may be related to the development of insulin resistance in chronic schizophreniapatients in Taiwan.
Authors: A Taniguchi; M Fukushima; M Sakai; K Kataoka; I Nagata; K Doi; H Arakawa; S Nagasaka; K Tokuyama; Y Nakai Journal: Metabolism Date: 2000-08 Impact factor: 8.694
Authors: Lonneke J M van Nimwegen; Jitschak G Storosum; Regje M E Blumer; Gideon Allick; Henk W Venema; Lieuwe de Haan; Hiske Becker; Therese van Amelsvoort; Mariette T Ackermans; Eric Fliers; Mireille J M Serlie; Hans P Sauerwein Journal: J Clin Endocrinol Metab Date: 2007-11-20 Impact factor: 5.958
Authors: J Walston; K Silver; C Bogardus; W C Knowler; F S Celi; S Austin; B Manning; A D Strosberg; M P Stern; N Raben Journal: N Engl J Med Date: 1995-08-10 Impact factor: 91.245