Literature DB >> 21084190

Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication.

Casey R Dorr1, Sergiy Yemets, Oksana Kolomitsyna, Pavel Krasutsky, Louis M Mansky.   

Abstract

Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21084190      PMCID： PMC3053071          DOI： 10.1016/j.bmcl.2010.10.078

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  23 in total

1.  The long cytoplasmic tail of gp41 is required in a cell type-dependent manner for HIV-1 envelope glycoprotein incorporation into virions.

Authors:  T Murakami; E O Freed
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

2.  Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses.

Authors:  M A Vodicka; W C Goh; L I Wu; M E Rogel; S R Bartz; V L Schweickart; C J Raport; M Emerman
Journal:  Virology       Date:  1997-06-23       Impact factor: 3.616

3.  3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro.

Authors:  Michael Sakalian; Curtis P McMurtrey; Frederick J Deeg; Christopher W Maloy; Feng Li; Carl T Wild; Karl Salzwedel
Journal:  J Virol       Date:  2006-06       Impact factor: 5.103

4.  Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles.

Authors:  Jing Zhou; Li Huang; David L Hachey; Chin Ho Chen; Christopher Aiken
Journal:  J Biol Chem       Date:  2005-10-25       Impact factor: 5.157

5.  Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.

Authors:  F Hashimoto; Y Kashiwada; L M Cosentino; C H Chen; P E Garrett; K H Lee
Journal:  Bioorg Med Chem       Date:  1997-12       Impact factor: 3.641

6.  In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat).

Authors:  Catherine S Adamson; Sherimay D Ablan; Ioana Boeras; Ritu Goila-Gaur; Ferri Soheilian; Kunio Nagashima; Feng Li; Karl Salzwedel; Michael Sakalian; Carl T Wild; Eric O Freed
Journal:  J Virol       Date:  2006-09-06       Impact factor: 5.103

7.  Role of the human T-cell leukemia virus type 1 PTAP motif in Gag targeting and particle release.

Authors:  Irene J Dorweiler; Susan J Ruone; Huating Wang; Richard W Burry; Louis M Mansky
Journal:  J Virol       Date:  2006-04       Impact factor: 5.103

8.  PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing.

Authors:  F Li; R Goila-Gaur; K Salzwedel; N R Kilgore; M Reddick; C Matallana; A Castillo; D Zoumplis; D E Martin; J M Orenstein; G P Allaway; E O Freed; C T Wild
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-22       Impact factor: 11.205

9.  Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation.

Authors:  Jing Zhou; Xiong Yuan; David Dismuke; Brett M Forshey; Christopher Lundquist; Kuo-Hsiung Lee; Christopher Aiken; Chin Ho Chen
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

10.  The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid.

Authors:  Jing Zhou; Chin Ho Chen; Christopher Aiken
Journal:  Retrovirology       Date:  2004-06-29       Impact factor: 4.602
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  2 in total

Review 1.  Recent advances in natural anti-HIV triterpenoids and analogs.

Authors:  Hai-Feng Wu; Susan L Morris-Natschke; Xu-Dong Xu; Mei-Hua Yang; Yung-Yi Cheng; Shi-Shan Yu; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2020-07-14       Impact factor: 12.944

2.  Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative luciferase-Vpr packaging-based assay.

Authors:  Gaëlle Gonzalez; Sandrina DaFonseca; Elisabeth Errazuriz; Pascale Coric; Florence Souquet; Serge Turcaud; Pierre Boulanger; Serge Bouaziz; Saw See Hong
Journal:  PLoS One       Date:  2011-11-03       Impact factor: 3.240
  2 in total

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