| Literature DB >> 21084121 |
Franca R Guerini1, Elisabetta Bolognesi, Matteo Chiappedi, Annalisa De Silvestri, Alessandro Ghezzo, Michela Zanette, Beatrice Rusconi, Salvatorica Manca, Stefano Sotgiu, Cristina Agliardi, Mario Clerici.
Abstract
To verify correlations between HLA and autism spectrum disorders (ASD) we studied 61 Italian families with an ASD child; results showed such correlation in 65% of cases. Case-control and TDT analysis of intrafamilial transmission of SNPs, Msats, and HLA markers surrounding the α and β blocks, indicated significant positive associations for MOGc*131 and D6S2239*105 alleles in ASD, and a negative association of MIB *332 allele in healthy siblings. Polymorphism haplotype analysis demonstrated that two haplotypes comprising the TNF-238(G)-TNF-308(G)-MIB*332-HLA-B*38-HLA-Cw*12 and the D6S265*218-HLA-A*23-MOGc*131-rs2857766(G) alleles are more frequently transmitted to ASD. MOGc and MIB loci are linked with ASD in Italian patients.Entities:
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Year: 2010 PMID： 21084121 DOI： 10.1016/j.jneuroim.2010.10.019
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478