| Literature DB >> 21082790 |
Hannah E Bartrum1, David C Blakemore, Christopher J Moody, Christopher J Hayes.
Abstract
We have developed an in-flow process for the synthesis of β-keto esters via the BF(3)·OEt(2)-catalyzed formal C-H insertion of ethyl diazoacetate into aldehydes. The β-keto esters were then condensed with a range of amidines to give a variety of 2,6-substituted pyrimidin-4-ols.Entities:
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Year: 2010 PMID： 21082790 DOI： 10.1021/jo101783m
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354