Literature DB >> 21082271

Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells.

Eunjin Shin1, Chul Lee, Sang Hyun Sung, Young Choong Kim, Bang Yeon Hwang, Mi Kyeong Lee.   

Abstract

The CHCl(3) fraction of Cnidium monnieri fruits significantly inhibited the proliferation of hepatic stellate cells in an in-vitro assay system employing HSC-T6 hepatic stellate cell lines. Activity-guided fractionation of the CHCl(3) fraction of C. monnieri led to the isolation of ten coumarins: osthol (1), meranzin (2), auraptenol (3), meranzin hydrate (4), 7-hydroxy-8-methoxy coumarin (5), imperatorin (6), xanthotoxol (7), xanthotoxin (8), bergapten (9) and isopimpinellin (10). Of these, compounds 1 and 6 significantly inhibited proliferation of HSCs in a time- and concentration-dependent manner. In addition, compounds 1 and 6 significantly reduced collagen content in HSC-T6 cells.

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Year:  2010        PMID： 21082271     DOI： 10.1007/s11418-010-0485-7

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  13 in total

Review 1.  Hepatic stellate cells: a target for the treatment of liver fibrosis.

Authors:  J Wu; M A Zern
Journal:  J Gastroenterol       Date:  2000       Impact factor: 7.527

2.  Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity.

Authors:  Ju Sun Kim; Jin Cheul Kim; Sang Hee Shim; Eun Ju Lee; WenYi Jin; KiHwan Bae; Kun Ho Son; Hyun Pyo Kim; Sam Sik Kang; Hyeun Wook Chang
Journal:  Arch Pharm Res       Date:  2006-08       Impact factor: 4.946

Review 3.  Mechanisms of liver fibrosis.

Authors:  Shigeki Tsukada; Christopher J Parsons; Richard A Rippe
Journal:  Clin Chim Acta       Date:  2005-09-01       Impact factor: 3.786

Review 4.  Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy.

Authors:  D Li; S L Friedman
Journal:  J Gastroenterol Hepatol       Date:  1999-07       Impact factor: 4.029

5.  Coumarins from the fruits of Cnidium monnieri.

Authors:  J N Cai; P Basnet; Z T Wang; K Komatsu; L S Xu; T Tani
Journal:  J Nat Prod       Date:  2000-04       Impact factor: 4.050

Review 6.  Liver fibrosis.

Authors:  Ramón Bataller; David A Brenner
Journal:  J Clin Invest       Date:  2005-02       Impact factor: 14.808

7.  Nonvolatiles of commercial lime and grapefruit oils separated by high-speed countercurrent chromatography.

Authors:  Wolfgang Feger; Herbert Brandauer; Paulina Gabris; Herta Ziegler
Journal:  J Agric Food Chem       Date:  2006-03-22       Impact factor: 5.279

8.  Carbenoxolone inhibits DNA synthesis and collagen gene expression in rat hepatic stellate cells in culture.

Authors:  Naoki Uyama; Yasuyuki Shimahara; Hiroaki Okuyama; Norifumi Kawada; Shoko Kamo; Kazuo Ikeda; Yoshio Yamaoka
Journal:  J Hepatol       Date:  2003-11       Impact factor: 25.083

9.  Green tea polyphenol epigallocatechin-3-gallate inhibits platelet-derived growth factor-induced proliferation of human hepatic stellate cell line LI90.

Authors:  Ryuichiro Sakata; Takato Ueno; Toru Nakamura; Masaharu Sakamoto; Takuji Torimura; Michio Sata
Journal:  J Hepatol       Date:  2004-01       Impact factor: 25.083

10.  Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells.

Authors:  Mi Kyeong Lee; Hyekyung Yang; Jeong Seon Yoon; Eun Ju Jeong; Do Yoon Kim; Na Ry Ha; Sang Hyun Sung; Young Choong Kim
Journal:  Arch Pharm Res       Date:  2008-08-14       Impact factor: 4.946
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  4 in total

1.  Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells.

Authors:  Yalda Shokoohinia; Leila Hosseinzadeh; Maryam Alipour; Ali Mostafaie; Hamid-Reza Mohammadi-Motlagh
Journal:  Adv Pharmacol Sci       Date:  2014-09-03

2.  Metabolic Profile of C-Prenyl Coumarins Using Mass Spectrometry-Based Metabolomics.

Authors:  Yan Cheng; Xiaofang Ma; Qi Zhao; Chunyan Wang; Dongmei Yan; Fei Li
Journal:  Molecules       Date:  2021-10-29       Impact factor: 4.411

Review 3.  Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine.

Authors:  Zhong-Rong Zhang; Wing Nang Leung; Ho Yee Cheung; Chun Wai Chan
Journal:  Evid Based Complement Alternat Med       Date:  2015-07-13       Impact factor: 2.629

4.  8-Alkylcoumarins from the fruits of Cnidium monnieri protect against hydrogen peroxide induced oxidative stress damage.

Authors:  Chi-I Chang; Wan-Chiao Hu; Che-Piao Shen; Ban-Dar Hsu; Wei-Yong Lin; Ping-Jyun Sung; Wei-Hsien Wang; Jin-Bin Wu; Yueh-Hsiung Kuo
Journal:  Int J Mol Sci       Date:  2014-03-17       Impact factor: 5.923
  4 in total

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