Literature DB >> 21082113

Synthetic oligodeoxynucleotide purification by polymerization of failure sequences.

Shiyue Fang1, Suntara Fueangfung, Xi Lin, Xiang Zhang, Wenpeng Mai, Lanrong Bi, Sarah A Green.   

Abstract

Synthetic oligodeoxynucleotide is purified by capping failure sequences with an acrylated phosphoramidite followed by polymerization and product extraction. The method is suitable for large scale oligonucleotide drug purification.

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Year:  2010        PMID： 21082113     DOI： 10.1039/c0cc04374e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Dim and Dmoc Protecting Groups for Oligodeoxynucleotide Synthesis.

Authors:  Shiyue Fang; Dhananjani Eriyagama; Yinan Yuan; Shahien Shahsavari; Jinsen Chen; Xi Lin; Bhaskar Halami
Journal:  Curr Protoc Nucleic Acid Chem       Date:  2020-09

2.  A High-Throughput Process for the Solid-Phase Purification of Synthetic DNA Sequences.

Authors:  Andrzej Grajkowski; Jacek Cieślak; Serge L Beaucage
Journal:  Curr Protoc Nucleic Acid Chem       Date:  2017-06-19

3.  Non-Chromatographic Purification of Synthetic RNA Using Bio-Orthogonal Chemistry.

Authors:  Muhan He; Xunshen Wu; Song Mao; Phensinee Haruehanroengra; Irfan Khan; Jia Sheng; Maksim Royzen
Journal:  Curr Protoc       Date:  2021-09
  3 in total

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