Literature DB >> 2108188

Transforming growth factors type beta 1 and beta 2 suppress rat astrocyte autoantigen presentation and antagonize hyperinduction of class II major histocompatibility complex antigen expression by interferon-gamma and tumor necrosis factor-alpha.

H J Schluesener1.   

Abstract

The transforming growth factors (TGF) type beta 1 and beta 2 are regulatory cytokines strongly affecting rat astrocyte immune functions. Both cytokines suppressed presentation of autoantigen by astrocytes: highly encephalitogenic T cells cocultured with TGF-beta-treated astrocytes in the presence of myelin basic protein did not become activated to transfer experimental allergic encephalomyelitis, a central nervous system (CNS) autoimmune disease. Furthermore, TGF-beta 1 and -beta 2 antagonized hyperinduction of astrocyte major histocompatibility complex (MHC) class II antigen expression by interferon-gamma and tumor necrosis factor-alpha. Thus, TGF-beta might be a potential regulator of CNS inflammation.

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Year:  1990        PMID： 2108188     DOI： 10.1016/0165-5728(90)90134-9

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  15 in total

1.  Immunophenotypic analysis of infiltrating leukocytes and microglia in an experimental rat glioma.

Authors:  T Morioka; T Baba; K L Black; W J Streit
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

Review 2.  Immune control of the brain.

Authors:  M Bradl
Journal:  Springer Semin Immunopathol       Date:  1996

3.  Analysis of the secretion pattern of monocyte chemotactic protein-1 (MCP-1) and transforming growth factor-beta 2 (TGF-beta2) by human retinal pigment epithelial cells.

Authors:  G M Holtkamp; A F De Vos; R Peek; A Kijlsta
Journal:  Clin Exp Immunol       Date:  1999-10       Impact factor: 4.330

4.  Suppression of TGF-beta1 in human gliomas by retroviral gene transfection enhances susceptibility to LAK cells.

Authors:  R Yamanaka; R Tanaka; S Yoshida; T Saitoh; K Fujita; H Naganuma
Journal:  J Neurooncol       Date:  1999-05       Impact factor: 4.130

5.  Interactions between interferon gamma and retinoic acid with transforming growth factor beta in the induction of immune recognition molecules.

Authors:  R Darley; A Morris; J Passas; W Bateman
Journal:  Cancer Immunol Immunother       Date:  1993-07       Impact factor: 6.968

6.  Effects of transforming growth factor-beta on murine astrocyte glutamine synthetase activity. Implications in neuronal injury.

Authors:  C C Chao; S Hu; M Tsang; J Weatherbee; T W Molitor; W R Anderson; P K Peterson
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

Review 7.  Cytokine gene expression within the central nervous system.

Authors:  T Nitta
Journal:  Cell Mol Neurobiol       Date:  1998-12       Impact factor: 5.046

8.  Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

Authors:  A Miller; O Lider; A B Roberts; M B Sporn; H L Weiner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

9.  Novel role of TGF-beta in differential astrocyte-TIMP-1 regulation: implications for HIV-1-dementia and neuroinflammation.

Authors:  Alok Dhar; Jessica Gardner; Kathleen Borgmann; Li Wu; Anuja Ghorpade
Journal:  J Neurosci Res       Date:  2006-05-15       Impact factor: 4.164

10.  Expression of transforming growth factor-beta 1 and interleukin-1 beta mRNA in rat brain following transient forebrain ischemia.

Authors:  C Wiessner; J Gehrmann; D Lindholm; R Töpper; G W Kreutzberg; K A Hossmann
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088
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