OBJECTIVES: Our aim was to compare retrospectively hepatic venous and delayed phase images for the detection of tumour washout during multiphasic multidetector row CT (MDCT) of the liver in patients with hepatocellular carcinoma (HCC). METHODS: 30 cirrhotic patients underwent multiphasic MDCT in the 90 days before liver transplantation. MDCT was performed before contrast medium administration and during hepatic arterial hepatic venous and delayed phases, images were obtained at 12, 55 and 120 s after trigger threshold. Two radiologists qualitatively evaluated images for lesion attenuation. Tumour washout was evaluated subjectively and objectively. Tumour-to-liver contrast (TLC) was measured for all pathologically proven HCCs. RESULTS: 48 HCCs were detected at MDCT. 46 of the 48 tumours (96%) appeared as either hyper- or isoattenuating during the hepatic arterial phase subjective washout was present in 15 HCCs (33%) during the hepatic venous phase and in 35 (76%) during the delayed phase (p<0.001, McNemar's test). Objective washout was present in 30 of the 46 HCCs (65%) during the hepatic venous phase and in 42 of the HCCs (91%) during the delayed phase (p=0.001). The delayed phase yielded significantly higher mean TLC absolute values compared with the hepatic venous phase (-16.1±10.8 HU vs -10.5±10.2 HU; p<0.001). CONCLUSIONS: The delayed phase is superior to the hepatic venous phase for detection of tumour washout of pathologically proven HCC in cirrhotic patients.
OBJECTIVES: Our aim was to compare retrospectively hepatic venous and delayed phase images for the detection of tumour washout during multiphasic multidetector row CT (MDCT) of the liver in patients with hepatocellular carcinoma (HCC). METHODS: 30 cirrhotic patients underwent multiphasic MDCT in the 90 days before liver transplantation. MDCT was performed before contrast medium administration and during hepatic arterial hepatic venous and delayed phases, images were obtained at 12, 55 and 120 s after trigger threshold. Two radiologists qualitatively evaluated images for lesion attenuation. Tumour washout was evaluated subjectively and objectively. Tumour-to-liver contrast (TLC) was measured for all pathologically proven HCCs. RESULTS: 48 HCCs were detected at MDCT. 46 of the 48 tumours (96%) appeared as either hyper- or isoattenuating during the hepatic arterial phase subjective washout was present in 15 HCCs (33%) during the hepatic venous phase and in 35 (76%) during the delayed phase (p<0.001, McNemar's test). Objective washout was present in 30 of the 46 HCCs (65%) during the hepatic venous phase and in 42 of the HCCs (91%) during the delayed phase (p=0.001). The delayed phase yielded significantly higher mean TLC absolute values compared with the hepatic venous phase (-16.1±10.8 HU vs -10.5±10.2 HU; p<0.001). CONCLUSIONS: The delayed phase is superior to the hepatic venous phase for detection of tumour washout of pathologically proven HCC in cirrhotic patients.
Authors: O Matsui; M Kadoya; T Kameyama; J Yoshikawa; T Takashima; Y Nakanuma; M Unoura; K Kobayashi; R Izumi; M Ida Journal: Radiology Date: 1991-02 Impact factor: 11.105
Authors: Fred A Mettler; Bruce R Thomadsen; Mythreyi Bhargavan; Debbie B Gilley; Joel E Gray; Jill A Lipoti; John McCrohan; Terry T Yoshizumi; Mahadevappa Mahesh Journal: Health Phys Date: 2008-11 Impact factor: 1.316
Authors: Ruth C Carlos; H Myra Kim; Hero K Hussain; Issac R Francis; Hanh V Nghiem; A Mark Fendrick Journal: AJR Am J Roentgenol Date: 2003-04 Impact factor: 3.959
Authors: K Ohtomo; R L Baron; G D Dodd; M P Federle; W J Miller; W L Campbell; S R Confer; K M Weber Journal: Radiology Date: 1993-07 Impact factor: 11.105
Authors: Eric C Ehman; Spencer C Behr; Sarah E Umetsu; Nicholas Fidelman; Ben M Yeh; Linda D Ferrell; Thomas A Hope Journal: Abdom Radiol (NY) Date: 2016-05
Authors: Jan B Hinrichs; Hoen-Oh Shin; Daniel Kaercher; Davut Hasdemir; Tim Murray; Till Kaireit; Carolin Lutat; Arndt Vogel; Bernhard C Meyer; Frank K Wacker; Thomas Rodt Journal: Eur Radiol Date: 2016-01-14 Impact factor: 5.315