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Literature DB >> 21079596

Grand challenge commentary: Chemical transdifferentiation and regenerative medicine.

Abstract

The ability to alter cell identity with small molecules represents a powerful approach to restore biological function lost because of cellular deficiency. Developing this capability through advances in chemical biology could have an enormous impact on human health.

Entities: Disease Species

Mesh：

Substances：
Small Molecule Libraries

Year: 2010 PMID： 21079596 DOI： 10.1038/nchembio.472

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

15 in total

1. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.

Authors: Zoltan Arany; Bridget K Wagner; Yanhong Ma; Jessica Chinsomboon; Dina Laznik; Bruce M Spiegelman
Journal: Proc Natl Acad Sci U S A Date: 2008-03-17 Impact factor: 11.205

2. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.

Authors: Haley Hieronymus; Justin Lamb; Kenneth N Ross; Xiao P Peng; Cristina Clement; Anna Rodina; Maria Nieto; Jinyan Du; Kimberly Stegmaier; Srilakshmi M Raj; Katherine N Maloney; Jon Clardy; William C Hahn; Gabriela Chiosis; Todd R Golub
Journal: Cancer Cell Date: 2006-09-28 Impact factor: 31.743

3. MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts.

Authors: S J Tapscott; R L Davis; M J Thayer; P F Cheng; H Weintraub; A B Lassar
Journal: Science Date: 1988-10-21 Impact factor: 47.728

Review 4. A complex task? Direct modulation of transcription factors with small molecules.

Authors: Angela N Koehler
Journal: Curr Opin Chem Biol Date: 2010-04-13 Impact factor: 8.822

5. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.

Authors: Patrick Collombat; Xiaobo Xu; Philippe Ravassard; Beatriz Sosa-Pineda; Sébastien Dussaud; Nils Billestrup; Ole D Madsen; Palle Serup; Harry Heimberg; Ahmed Mansouri
Journal: Cell Date: 2009-08-07 Impact factor: 41.582

6. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors: Kazutoshi Takahashi; Shinya Yamanaka
Journal: Cell Date: 2006-08-10 Impact factor: 41.582

7. Small-molecule inducers of insulin expression in pancreatic alpha-cells.

Authors: Dina Fomina-Yadlin; Stefan Kubicek; Deepika Walpita; Vlado Dancik; Jacob Hecksher-Sørensen; Joshua A Bittker; Tanaz Sharifnia; Alykhan Shamji; Paul A Clemons; Bridget K Wagner; Stuart L Schreiber
Journal: Proc Natl Acad Sci U S A Date: 2010-08-09 Impact factor: 11.205

8. Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.

Authors: Angela N Koehler; Alykhan F Shamji; Stuart L Schreiber
Journal: J Am Chem Soc Date: 2003-07-16 Impact factor: 15.419

9. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

Authors: Justin K Ichida; Joel Blanchard; Kelvin Lam; Esther Y Son; Julia E Chung; Dieter Egli; Kyle M Loh; Ava C Carter; Francesco P Di Giorgio; Kathryn Koszka; Danwei Huangfu; Hidenori Akutsu; David R Liu; Lee L Rubin; Kevin Eggan
Journal: Cell Stem Cell Date: 2009-10-08 Impact factor: 24.633

Grand challenge commentary: Chemical transdifferentiation and regenerative medicine.

1. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.

2. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.

3. MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts.

Review 4. A complex task? Direct modulation of transcription factors with small molecules.

5. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.

6. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

7. Small-molecule inducers of insulin expression in pancreatic alpha-cells.

8. Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.

9. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

10. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

Review 1. Targeting the pancreatic β-cell to treat diabetes.

2. Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming.

3. Reprogramming cells for brain repair.

4. Can Human Oral Mucosa Stem Cells Differentiate to Corneal Epithelia?