UNLABELLED: The aim of this work was to preliminarily evaluate the sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of (68)Ga-citrate PET/CT in a population of patients with suspected bone infections. METHODS: We enrolled 31 patients with suspected osteomyelitis or diskitis who underwent a total of forty (68)Ga-citrate PET/CT scans. The results were compared with different combinations of diagnostic procedures (MRI, radiography, CT, or white blood cell scintigraphy), biopsy (when diagnostic), and follow-up data (at least 1 y) to determine the performance of (68)Ga-citrate PET/CT. RESULTS: We found a sensitivity of 100%, a specificity of 76%, a positive predictive value of 85%, a negative predictive value of 100%, and an overall accuracy of 90%. CONCLUSION: Although preliminary, these data confirm a possible role for (68)Ga-citrate in the diagnosis of bone infections, especially in consideration of its favorable characteristics.
UNLABELLED: The aim of this work was to preliminarily evaluate the sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of (68)Ga-citrate PET/CT in a population of patients with suspected bone infections. METHODS: We enrolled 31 patients with suspected osteomyelitis or diskitis who underwent a total of forty (68)Ga-citrate PET/CT scans. The results were compared with different combinations of diagnostic procedures (MRI, radiography, CT, or white blood cell scintigraphy), biopsy (when diagnostic), and follow-up data (at least 1 y) to determine the performance of (68)Ga-citrate PET/CT. RESULTS: We found a sensitivity of 100%, a specificity of 76%, a positive predictive value of 85%, a negative predictive value of 100%, and an overall accuracy of 90%. CONCLUSION: Although preliminary, these data confirm a possible role for (68)Ga-citrate in the diagnosis of bone infections, especially in consideration of its favorable characteristics.
Authors: Douglas S MacPherson; Kimberly Fung; Brendon E Cook; Lynn C Francesconi; Brian M Zeglis Journal: Dalton Trans Date: 2019-10-07 Impact factor: 4.390
Authors: Ole L Nielsen; Pia Afzelius; Dirk Bender; Henrik C Schønheyder; Páll S Leifsson; Karin M Nielsen; Jytte O Larsen; Svend B Jensen; Aage Ko Alstrup Journal: Am J Nucl Med Mol Imaging Date: 2015-01-15
Authors: Giorgio Treglia; Mariarosa Pascale; Elena Lazzeri; Wouter van der Bruggen; Roberto C Delgado Bolton; Andor W J M Glaudemans Journal: Eur J Nucl Med Mol Imaging Date: 2019-11-15 Impact factor: 9.236
Authors: Pia Afzelius; Ole L Nielsen; Aage Ko Alstrup; Dirk Bender; Páll S Leifsson; Svend B Jensen; Henrik C Schønheyder Journal: Am J Nucl Med Mol Imaging Date: 2016-01-28