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Literature DB >> 21078554

Protein kinase affinity reagents based on a 5-aminoindazole scaffold.

Ratika Krishnamurty¹, Amanda M Brock, Dustin J Maly.

Abstract

Affinity reagents that target protein kinases are powerful tools for signal transduction research. Here, we describe a general set of kinase ligands based on a 5-aminoindazole scaffold. This scaffold can readily be derivatized with diverse binding elements and immobilized analogs allow selective enrichment of protein kinases from complex mixtures.

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Year: 2010 PMID： 21078554 PMCID： PMC4138815 DOI： 10.1016/j.bmcl.2010.10.069

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

21 in total

Review 1. The protein kinase complement of the human genome.

Authors: G Manning; D B Whyte; R Martinez; T Hunter; S Sudarsanam
Journal: Science Date: 2002-12-06 Impact factor: 47.728

2. An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

Authors: Klaus Godl; Josef Wissing; Alexander Kurtenbach; Peter Habenberger; Stephanie Blencke; Heidrun Gutbrod; Kostadinos Salassidis; Matthias Stein-Gerlach; Andrea Missio; Matt Cotten; Henrik Daub
Journal: Proc Natl Acad Sci U S A Date: 2003-12-10 Impact factor: 11.205

Review 3. Protein kinases--the major drug targets of the twenty-first century?

Authors: Philip Cohen
Journal: Nat Rev Drug Discov Date: 2002-04 Impact factor: 84.694

4. Toward a pharmacophore for kinase frequent hitters.

Authors: Alex M Aronov; Mark A Murcko
Journal: J Med Chem Date: 2004-11-04 Impact factor: 7.446

Review 5. Targeting cancer with small molecule kinase inhibitors.

Authors: Jianming Zhang; Priscilla L Yang; Nathanael S Gray
Journal: Nat Rev Cancer Date: 2009-01 Impact factor: 60.716

6. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

Authors: Henrik Daub; Jesper V Olsen; Michaela Bairlein; Florian Gnad; Felix S Oppermann; Roman Körner; Zoltán Greff; György Kéri; Olaf Stemmann; Matthias Mann
Journal: Mol Cell Date: 2008-08-08 Impact factor: 17.970

7. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.

Authors: L Meijer; A M Thunnissen; A W White; M Garnier; M Nikolic; L H Tsai; J Walter; K E Cleverley; P C Salinas; Y Z Wu; J Biernat; E M Mandelkow; S H Kim; G R Pettit
Journal: Chem Biol Date: 2000-01

8. A chemical and phosphoproteomic characterization of dasatinib action in lung cancer.

Authors: Jiannong Li; Uwe Rix; Bin Fang; Yun Bai; Arthur Edwards; Jacques Colinge; Keiryn L Bennett; Jingchun Gao; Lanxi Song; Steven Eschrich; Giulio Superti-Furga; John Koomen; Eric B Haura
Journal: Nat Chem Biol Date: 2010-02-28 Impact factor: 15.040

Protein kinase affinity reagents based on a 5-aminoindazole scaffold.

Review 1. The protein kinase complement of the human genome.

2. An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

Review 3. Protein kinases--the major drug targets of the twenty-first century?

4. Toward a pharmacophore for kinase frequent hitters.

Review 5. Targeting cancer with small molecule kinase inhibitors.

6. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

7. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.

8. A chemical and phosphoproteomic characterization of dasatinib action in lung cancer.

9. Global analysis of protein expression in yeast.

10. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.

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