BACKGROUND: We recently demonstrated an immediate immunodepressive state after acute ischemic stroke in humans. METHODS: In the present study, we prospectively analyzed immune responses in patients with middle cerebral artery stroke (n=20), acute myocardial infarction (n=20) and healthy controls (n=20, also matched for age and gender). RESULTS: Compared to controls, a rapid depression of monocytic HLA-DR expression and a defective lymphocytic IFN-γ production was obvious after ischemic stroke or myocardial infarction, while total counts of leukocytes and monocytes were significantly higher after myocardial infarction. A T cell-mediated lymphopenia was accentuated in patients with severe stroke, obviously predisposing these patients for nosocomial infections. CONCLUSIONS: Our data reveal an immediate and to some extent differential suppression of cell-mediated immune responses after ischemic stroke or myocardial infarction respectively. Copyright Â
BACKGROUND: We recently demonstrated an immediate immunodepressive state after acute ischemic stroke in humans. METHODS: In the present study, we prospectively analyzed immune responses in patients with middle cerebral artery stroke (n=20), acute myocardial infarction (n=20) and healthy controls (n=20, also matched for age and gender). RESULTS: Compared to controls, a rapid depression of monocytic HLA-DR expression and a defective lymphocytic IFN-γ production was obvious after ischemic stroke or myocardial infarction, while total counts of leukocytes and monocytes were significantly higher after myocardial infarction. A T cell-mediated lymphopenia was accentuated in patients with severe stroke, obviously predisposing these patients for nosocomial infections. CONCLUSIONS: Our data reveal an immediate and to some extent differential suppression of cell-mediated immune responses after ischemic stroke or myocardial infarction respectively. Copyright Â
Authors: Xiaoyin Wang; Junya Takagawa; Viola C Lam; Daniel J Haddad; Diana L Tobler; Pamela Y Mok; Yan Zhang; Brian T Clifford; Kranthi Pinnamaneni; Shereen A Saini; Robert Su; Maya J Bartel; Richard E Sievers; Larry Carbone; Scott Kogan; Yerem Yeghiazarians; Michelle Hermiston; Matthew L Springer Journal: Sci Transl Med Date: 2011-09-14 Impact factor: 17.956
Authors: Anja M van der Laan; Ellis N Ter Horst; Ronak Delewi; Mark P V Begieneman; Paul A J Krijnen; Alexander Hirsch; Mehrdad Lavaei; Matthias Nahrendorf; Anton J Horrevoets; Hans W M Niessen; Jan J Piek Journal: Eur Heart J Date: 2013-08-21 Impact factor: 29.983