| Literature DB >> 21078519 |
Violeta Marković1, Slavica Erić, Zorica D Juranić, Tatjana Stanojković, Ljubinka Joksović, Branislav Ranković, Marijana Kosanić, Milan D Joksović.
Abstract
A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors.Entities:
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Year: 2010 PMID： 21078519 DOI： 10.1016/j.bioorg.2010.10.003
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275