| Literature DB >> 21077764 |
Jennifer L Oliveira1, Kenneth Swanson, Patricia Wendt, Thomas D Caughey, James D Hoyer.
Abstract
A new β hemoglobin (Hb) variant, Hb Cambridge-MA [β144(HC1)β146(HC3)Lys-Tyr-His→0 (AAG>TAG) (HGVS: HBB c.433 A>T] is described. The variant was characterized by high performance liquid chromatography (HPLC), alkaline, acid, globin chain and capillary electrophoresis, isoelectric focusing (IEF), heat and isopropanol stability, p50 analyses, intact globin mass spectrometry (MS) and DNA sequencing. The new variant shows high oxygen (O₂) affinity and is associated with mild polycythemia.Entities:
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Year: 2010 PMID： 21077764 DOI： 10.3109/03630269.2010.526921
Source DB: PubMed Journal: Hemoglobin ISSN： 0363-0269 Impact factor: 0.849