Literature DB >> 21077066

Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions.

Jun Guo1, Guojun Chen, Xinghai Ning, Margreet A Wolfert, Xiuru Li, Bingqian Xu, Geert-Jan Boons.   

Abstract

Organomicelles modified by surface dibenzylcyclooctyne moieties can conveniently be functionalized by strain-promoted alkyne-azide cycloadditions. The ligation approach is highly efficient, does not require toxic reagents and is compatible with a wide variety of functional modules. Interactions of proteins with surface ligands of the micelles have been studied by AFM, which revealed that it leads to disassembly of the particles thereby providing a mechanism for triggered drug release.

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Year:  2010        PMID： 21077066      PMCID： PMC3059085          DOI： 10.1002/chem.201002532

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  36 in total

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4.  Marrying click chemistry with polymerization: expanding the scope of polymeric materials.

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Review 9.  Nanocarriers as an emerging platform for cancer therapy.

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10.  A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems.

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  6 in total

Review 1.  Targeted polymeric therapeutic nanoparticles: design, development and clinical translation.

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2.  A chemo-mechanical tweezer for single-molecular characterization of soft materials.

Authors:  Jun Guo; Guojun Chen; Xinghai Ning; Xiuru Li; Jianfeng Zhou; Anna Jagielska; Bingqian Xu; Geert-Jan Boons
Journal:  Chemistry       Date:  2012-02-28       Impact factor: 5.236

3.  Exploring strain-promoted 1,3-dipolar cycloadditions of end functionalized polymers.

Authors:  Petr A Ledin; Nagesh Kolishetti; Manish S Hudlikar; Geert-Jan Boons
Journal:  Chemistry       Date:  2014-06-06       Impact factor: 5.236

4.  Multi-Functionalization of Polymers by Strain-Promoted Cycloadditions.

Authors:  Petr A Ledin; Nagesh Kolishetti; Geert-Jan Boons
Journal:  Macromolecules       Date:  2013-10-08       Impact factor: 5.985

5.  Rapid and Complete Surface Modification with Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ).

Authors:  Rickdeb Sen; Jorge Escorihuela; Floris van Delft; Han Zuilhof
Journal:  Angew Chem Int Ed Engl       Date:  2017-02-15       Impact factor: 15.336

6.  Protein-triggered supramolecular disassembly: insights based on variations in ligand location in amphiphilic dendrons.

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  6 in total

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