Literature DB >> 21076807

[New possibilities for automated diagnosis of dementia].

S Klöppel1.   

Abstract

Dementia is underdiagnosed and undertreated in Germany. Automatic diagnosing of dementia based on standard magnetic resonance imaging has the capacity to reduce diagnostic uncertainties. The algorithm learns a disease specific pattern of atrophy from training samples. It is independent from radiological expertise which may be scarce outside specialised centres and can be installed on MRT-machines or desktop PCs. It can also play its part in planning and conducting treatment trials by recruiting a sample with predicted fast future decline. Extension, based e.g. on resting state functional imaging are possible but are further away from clinical routine.

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Year:  2010        PMID: 21076807     DOI: 10.1007/s00115-010-3104-7

Source DB:  PubMed          Journal:  Nervenarzt        ISSN: 0028-2804            Impact factor:   1.214


  26 in total

1.  Prediction of response to donepezil in Alzheimer's disease: combined MRI analysis of the substantia innominata and SPECT measurement of cerebral perfusion.

Authors:  Hidekazu Kanetaka; Haruo Hanyu; Kentaro Hirao; Soichiro Shimizu; Tomohiko Sato; Tomotaka Akai; Toshihiko Iwamoto; Kiyoshi Koizumi
Journal:  Nucl Med Commun       Date:  2008-06       Impact factor: 1.690

Review 2.  Plasma biomarkers of Alzheimer's disease.

Authors:  Takeshi Kawarabayashi; Mikio Shoji
Journal:  Curr Opin Psychiatry       Date:  2008-05       Impact factor: 4.741

3.  Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease.

Authors:  Walter Koch; Stephan Teipel; Sophia Mueller; Jens Benninghoff; Maxmilian Wagner; Arun L W Bokde; Harald Hampel; Ute Coates; Maximilian Reiser; Thomas Meindl
Journal:  Neurobiol Aging       Date:  2010-06-11       Impact factor: 4.673

4.  Altered brain activation during a verbal working memory task in subjects with amnestic mild cognitive impairment.

Authors:  Arun L W Bokde; Michaela Karmann; Christine Born; Stefan J Teipel; Muamer Omerovic; Michael Ewers; Thomas Frodl; Eva Meisenzahl; Maximilian Reiser; Hans-Jürgen Möller; Harald Hampel
Journal:  J Alzheimers Dis       Date:  2010       Impact factor: 4.472

5.  Multivariate deformation-based analysis of brain atrophy to predict Alzheimer's disease in mild cognitive impairment.

Authors:  Stefan J Teipel; Christine Born; Michael Ewers; Arun L W Bokde; Maximilian F Reiser; Hans-Jürgen Möller; Harald Hampel
Journal:  Neuroimage       Date:  2007-07-18       Impact factor: 6.556

Review 6.  Brain morphometry and functional imaging techniques in dementia: methods, findings and relevance in forensic neurology.

Authors:  Stefan Klöppel
Journal:  Curr Opin Neurol       Date:  2009-12       Impact factor: 5.710

Review 7.  Core candidate neurochemical and imaging biomarkers of Alzheimer's disease.

Authors:  Harald Hampel; Katharina Bürger; Stefan J Teipel; Arun L W Bokde; Henrik Zetterberg; Kaj Blennow
Journal:  Alzheimers Dement       Date:  2007-12-21       Impact factor: 21.566

8.  Functional relevant loss of long association fibre tracts integrity in early Alzheimer's disease.

Authors:  Andreas Fellgiebel; Ingrid Schermuly; Alexander Gerhard; Isabel Keller; Juliane Albrecht; Carsten Weibrich; Matthias J Müller; Peter Stoeter
Journal:  Neuropsychologia       Date:  2007-12-23       Impact factor: 3.139

9.  Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index.

Authors:  Christos Davatzikos; Feng Xu; Yang An; Yong Fan; Susan M Resnick
Journal:  Brain       Date:  2009-05-04       Impact factor: 13.501

10.  Accuracy of dementia diagnosis: a direct comparison between radiologists and a computerized method.

Authors:  Stefan Klöppel; Cynthia M Stonnington; Josephine Barnes; Frederick Chen; Carlton Chu; Catriona D Good; Irina Mader; L Anne Mitchell; Ameet C Patel; Catherine C Roberts; Nick C Fox; Clifford R Jack; John Ashburner; Richard S J Frackowiak
Journal:  Brain       Date:  2008-10-03       Impact factor: 13.501

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  1 in total

1.  Dementia in People with a Turkish Migration Background: Experiences and Utilization of Healthcare Services.

Authors:  Jessica Monsees; Tim Schmachtenberg; Wolfgang Hoffmann; Amy Kind; Andrea Gilmore-Bykovskyi; Alice J Kim; Jochen René Thyrian
Journal:  J Alzheimers Dis       Date:  2020       Impact factor: 4.472

  1 in total

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