Literature DB >> 2107652

Interleukin 6 possibly induced by interleukin 1 beta in the pituitary gland stimulates the release of gonadotropins and prolactin.

M Yamaguchi1, N Matsuzaki, K Hirota, A Miyake, O Tanizawa.   

Abstract

The abilities of recombinant human interleukin 1 (IL-1) and IL-6 to induce release of FSH, LH and PRL from rat pituitary cells in vitro were examined. IL-1 and IL-6 induced significant releases of FSH, LH and PRL within 3 h. The extents of release of these compounds induced by IL-1 and IL-6 were similar to those induced by GnRH and TRH. Rat anterior pituitary cells released IL-6 spontaneously, and its release was enhanced by IL-1 beta. This effect of IL-1 beta was inhibited significantly by a rabbit anti-IL-1 beta antiserum. These findings suggest that IL-1 induced the release of IL-6 from rat pituitary, and that the released IL-6 stimulated the secretions of FSH, LH and PRL.

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Year:  1990        PMID： 2107652     DOI： 10.1530/acta.0.1220201

Source DB:  PubMed          Journal:  Acta Endocrinol (Copenh)        ISSN： 0001-5598


  12 in total

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