Literature DB >> 21076444

Klotho, FGF23, and FGF receptors in chronic kidney disease: a yin-yang situation?

Tilman B Drüeke1.   

Abstract

Secondary hyperparathyroidism in chronic kidney disease (CKD) develops in response to disturbances in calcium and phosphate metabolism associated with CKD, including FGF23 and klotho. FGF23 activates its receptor FGFR1, splice variant IIIC, in the parathyroid gland via a klotho-dependent mechanism and suppresses parathyroid hormone (PTH) secretion. Klotho also may regulate PTH secretion in an FGF23-independent mode, by modulating parathyroid Na+/K+-ATPase activity. The persistence of hyperparathyroidism with progressing CKD despite high serum FGF23 is indicative of FGF23 resistance.

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Year:  2010        PMID： 21076444     DOI： 10.1038/ki.2010.339

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  10 in total

Review 1.  Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.

Authors:  Ming Chang Hu; Kazuhiro Shiizaki; Makoto Kuro-o; Orson W Moe
Journal:  Annu Rev Physiol       Date:  2013       Impact factor: 19.318

Review 2.  Bone development: overview of bone cells and signaling.

Authors:  Anna Teti
Journal:  Curr Osteoporos Rep       Date:  2011-12       Impact factor: 5.096

3.  A correlation between decreased parathyroid α-Klotho and fibroblast growth factor receptor 1 expression with pathological category and parathyroid gland volume in dialysis patients.

Authors:  Junfang Yan; Chen Jingbo; Deguang Wang; Shengxue Xie; Liang Yuan; Xing Zhong; Li Hao
Journal:  Int Urol Nephrol       Date:  2015-03-07       Impact factor: 2.370

Review 4.  Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway.

Authors:  Peter S N Rowe
Journal:  Crit Rev Eukaryot Gene Expr       Date:  2012       Impact factor: 1.807

Review 5.  Molecular basis of Klotho: from gene to function in aging.

Authors:  Yuechi Xu; Zhongjie Sun
Journal:  Endocr Rev       Date:  2015-02-19       Impact factor: 19.871

Review 6.  Osteo-renal regulation of systemic phosphate metabolism.

Authors:  Mohammed Shawkat Razzaque
Journal:  IUBMB Life       Date:  2011-03-24       Impact factor: 3.885

Review 7.  The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled.

Authors:  Peter S N Rowe
Journal:  Cell Biochem Funct       Date:  2012-05-09       Impact factor: 3.685

8.  Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.

Authors:  Albina Nowak; Björn Friedrich; Ferruh Artunc; Andreas L Serra; Tobias Breidthardt; Raphael Twerenbold; Myriam Peter; Christian Mueller
Journal:  PLoS One       Date:  2014-07-03       Impact factor: 3.240

9.  Deregulated Renal Calcium and Phosphate Transport during Experimental Kidney Failure.

Authors:  Wilco P Pulskens; Melissa Verkaik; Fareeba Sheedfar; Ellen P van Loon; Bart van de Sluis; Mark G Vervloet; Joost G Hoenderop; René J Bindels
Journal:  PLoS One       Date:  2015-11-13       Impact factor: 3.240

10.  Effect of Salt Intervention on Serum Levels of Fibroblast Growth Factor 23 (FGF23) in Chinese Adults: An Intervention Study.

Authors:  Jia-Wen Hu; Yang Wang; Chao Chu; Jian-Jun Mu
Journal:  Med Sci Monit       Date:  2018-04-02
  10 in total

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