Literature DB >> 21076400

Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.

Nathan I Nicely1, S Moses Dennison, Leonard Spicer, Richard M Scearce, Garnett Kelsoe, Yoshihiro Ueda, Haiyan Chen, Hua-Xin Liao, S Munir Alam, Barton F Haynes.   

Abstract

The monoclonal antibody 13H11 shares part of its epitope in the HIV-1 gp41 membrane-proximal external region (MPER) with the rare, broadly neutralizing human antibody 2F5. Although 13H11 partially cross-blocked 2F5 binding, 13H11 is non-neutralizing and does not block 2F5 neutralization. We show that unlike 2F5, 13H11 binds to a well-defined helical MPER structure that is consistent with the structure of gp41 in a post-fusion six-helix bundle conformation.

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Year:  2010        PMID： 21076400      PMCID： PMC6081738          DOI： 10.1038/nsmb.1944

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  21 in total

1.  Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region.

Authors:  Gilad Ofek; Krisha McKee; Yongping Yang; Zhi-Yong Yang; Jeff Skinner; F Javier Guenaga; Richard Wyatt; Michael B Zwick; Gary J Nabel; John R Mascola; Peter D Kwong
Journal:  J Virol       Date:  2009-12-30       Impact factor: 5.103

2.  Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies.

Authors:  M B Zwick; M Wang; P Poignard; G Stiegler; H Katinger; D R Burton; P W Parren
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

3.  Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies.

Authors:  Pascal Poignard; Maxime Moulard; Edwin Golez; Veronique Vivona; Michael Franti; Sara Venturini; Meng Wang; Paul W H I Parren; Dennis R Burton
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

4.  Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41.

Authors:  Rosa M F Cardoso; Michael B Zwick; Robyn L Stanfield; Renate Kunert; James M Binley; Hermann Katinger; Dennis R Burton; Ian A Wilson
Journal:  Immunity       Date:  2005-02       Impact factor: 31.745

5.  The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes.

Authors:  S Munir Alam; Mildred McAdams; David Boren; Michael Rak; Richard M Scearce; Feng Gao; Zenaido T Camacho; Daniel Gewirth; Garnett Kelsoe; Pojen Chen; Barton F Haynes
Journal:  J Immunol       Date:  2007-04-01       Impact factor: 5.422

6.  Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

Authors:  Barton F Haynes; Judith Fleming; E William St Clair; Herman Katinger; Gabriela Stiegler; Renate Kunert; James Robinson; Richard M Scearce; Kelly Plonk; Herman F Staats; Thomas L Ortel; Hua-Xin Liao; S Munir Alam
Journal:  Science       Date:  2005-04-28       Impact factor: 47.728

7.  Recognition by human monoclonal antibodies of free and complexed peptides representing the prefusogenic and fusogenic forms of human immunodeficiency virus type 1 gp41.

Authors:  M K Gorny; S Zolla-Pazner
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

8.  Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodies.

Authors:  Wen Yuan; Xing Li; Marta Kasterka; Miroslaw K Gorny; Susan Zolla-Pazner; Joseph Sodroski
Journal:  AIDS Res Hum Retroviruses       Date:  2009-03       Impact factor: 2.205

9.  Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions.

Authors:  Victor Buzon; Ganesh Natrajan; David Schibli; Felix Campelo; Michael M Kozlov; Winfried Weissenhorn
Journal:  PLoS Pathog       Date:  2010-05-06       Impact factor: 6.823

10.  Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection.

Authors:  S Munir Alam; Richard M Scearce; Robert J Parks; Kelly Plonk; Steven G Plonk; Laura L Sutherland; Miroslaw K Gorny; Susan Zolla-Pazner; Stacie Vanleeuwen; M Anthony Moody; Shi-Mao Xia; David C Montefiori; Georgia D Tomaras; Kent J Weinhold; Salim Abdool Karim; Charles B Hicks; Hua-Xin Liao; James Robinson; George M Shaw; Barton F Haynes
Journal:  J Virol       Date:  2007-10-17       Impact factor: 5.103
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  28 in total

1.  Structural basis for HIV-1 neutralization by 2F5-like antibodies m66 and m66.6.

Authors:  Gilad Ofek; Brett Zirkle; Yongping Yang; Zhongyu Zhu; Krisha McKee; Baoshan Zhang; Gwo-Yu Chuang; Ivelin S Georgiev; Sijy O'Dell; Nicole Doria-Rose; John R Mascola; Dimiter S Dimitrov; Peter D Kwong
Journal:  J Virol       Date:  2013-12-11       Impact factor: 5.103

2.  Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation.

Authors:  S Munir Alam; Hua-Xin Liao; S Moses Dennison; Frederick Jaeger; Robert Parks; Kara Anasti; Andrew Foulger; Michele Donathan; Judith Lucas; Laurent Verkoczy; Nathan Nicely; Georgia D Tomaras; Garnett Kelsoe; Bing Chen; Thomas B Kepler; Barton F Haynes
Journal:  J Virol       Date:  2011-09-14       Impact factor: 5.103

3.  Application of antihelix antibodies in protein structure determination.

Authors:  Ji Won Kim; Songwon Kim; Haerim Lee; Geunyoung Cho; Sun Chang Kim; Hayyoung Lee; Mi Sun Jin; Jie-Oh Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2019-08-01       Impact factor: 11.205

4.  Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes.

Authors:  Jason S McLellan; Yongping Yang; Barney S Graham; Peter D Kwong
Journal:  J Virol       Date:  2011-05-25       Impact factor: 5.103

5.  A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.

Authors:  Ryan T Bushey; M Anthony Moody; Nathan L Nicely; Barton F Haynes; S Munir Alam; Stephen T Keir; Rex C Bentley; Kingshuk Roy Choudhury; Elizabeth B Gottlin; Michael J Campa; Hua-Xin Liao; Edward F Patz
Journal:  Cell Rep       Date:  2016-05-05       Impact factor: 9.423

6.  Metastability Gap in the Phase Diagram of Monoclonal IgG Antibody.

Authors:  Jacob B Rowe; Rachel A Cancel; Tyler D Evangelous; Rhiannon P Flynn; Sergei Pechenov; J Anand Subramony; Jifeng Zhang; Ying Wang
Journal:  Biophys J       Date:  2017-10-17       Impact factor: 4.033

7.  Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide.

Authors:  S Moses Dennison; Kara M Anasti; Frederick H Jaeger; Shelley M Stewart; Justin Pollara; Pinghuang Liu; Erika L Kunz; Ruijun Zhang; Nathan Vandergrift; Sallie Permar; Guido Ferrari; Georgia D Tomaras; Mattia Bonsignori; Nelson L Michael; Jerome H Kim; Jaranit Kaewkungwal; Sorachai Nitayaphan; Punnee Pitisuttithum; Supachai Rerks-Ngarm; Hua-Xin Liao; Barton F Haynes; S Munir Alam
Journal:  J Virol       Date:  2014-06-11       Impact factor: 5.103

8.  Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice.

Authors:  Kevin Wiehe; Nathan I Nicely; Bradley Lockwood; Masayuki Kuraoka; Kara Anasti; Sabrina Arora; Cindy M Bowman; Christina Stolarchuk; Robert Parks; Krissey E Lloyd; Shi-Mao Xia; Ryan Duffy; Xiaoying Shen; Christos A Kyratsous; Lynn E Macdonald; Andrew J Murphy; Richard M Scearce; M Anthony Moody; S Munir Alam; Laurent Verkoczy; Georgia D Tomaras; Garnett Kelsoe; Barton F Haynes
Journal:  J Immunol       Date:  2016-12-23       Impact factor: 5.422

9.  Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies.

Authors:  Jinsong Zhang; S Munir Alam; Hilary Bouton-Verville; Yao Chen; Amanda Newman; Shelley Stewart; Frederick H Jaeger; David C Montefiori; S Moses Dennison; Barton F Haynes; Laurent Verkoczy
Journal:  J Immunol       Date:  2014-01-24       Impact factor: 5.422

10.  Neutralizing IgG at the portal of infection mediates protection against vaginal simian/human immunodeficiency virus challenge.

Authors:  Katja Klein; Ronald S Veazey; Ranjit Warrier; Peter Hraber; Lara A Doyle-Meyers; Viviana Buffa; Hua-Xin Liao; Barton F Haynes; George M Shaw; Robin J Shattock
Journal:  J Virol       Date:  2013-08-21       Impact factor: 5.103
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