AIM: to describe the impact of tenofovir disoproxil fumarate (TDF) use on renal function in HIV-infected pediatric patients. DESIGN: it is a prospective, multicenter study. The setting consisted of five third-level pediatric hospitals in Spain. The study was conducted on patients aged 18 years and younger who had received TDF for at least 6 months. The intervention was based on the study of renal function parameters by urine and serum analyses. The main outcome measures were renal function results following at least 6 months of TDF therapy. RESULTS: forty patients were included (32 were white and 26 were diagnosed with AIDS). Median (range) duration of TDF treatment was 77 months (16-143). There were no significant changes in the estimated creatinine clearance. Urine osmolality was abnormal in eight of 37 patients, a decrease in tubular phosphate absorption was documented in 28 of 38 patients, and 33 of 37 patients had proteinuria. A statistically significant decrease in serum phosphate and potassium concentrations was observed during treatment (P = 0.005 and P = 0.003, respectively), as well as a significant relationship between final phosphate concentration and tubular phosphate absorption (P = 0.010). A negative correlation was found between phosphate concentration and time on TDF. CONCLUSIONS: TDF use showed a significant association with renal tubular dysfunction in HIV-infected pediatric patients. Periodic assessment of tubular function may be advisable in the follow-up of this population. 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
AIM: to describe the impact of tenofovir disoproxil fumarate (TDF) use on renal function in HIV-infected pediatricpatients. DESIGN: it is a prospective, multicenter study. The setting consisted of five third-level pediatric hospitals in Spain. The study was conducted on patients aged 18 years and younger who had received TDF for at least 6 months. The intervention was based on the study of renal function parameters by urine and serum analyses. The main outcome measures were renal function results following at least 6 months of TDF therapy. RESULTS: forty patients were included (32 were white and 26 were diagnosed with AIDS). Median (range) duration of TDF treatment was 77 months (16-143). There were no significant changes in the estimated creatinine clearance. Urine osmolality was abnormal in eight of 37 patients, a decrease in tubular phosphate absorption was documented in 28 of 38 patients, and 33 of 37 patients had proteinuria. A statistically significant decrease in serum phosphate and potassium concentrations was observed during treatment (P = 0.005 and P = 0.003, respectively), as well as a significant relationship between final phosphate concentration and tubular phosphate absorption (P = 0.010). A negative correlation was found between phosphate concentration and time on TDF. CONCLUSIONS:TDF use showed a significant association with renal tubular dysfunction in HIV-infected pediatricpatients. Periodic assessment of tubular function may be advisable in the follow-up of this population. 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors: Gregory M Lucas; Michael J Ross; Peter G Stock; Michael G Shlipak; Christina M Wyatt; Samir K Gupta; Mohamed G Atta; Kara K Wools-Kaloustian; Paul A Pham; Leslie A Bruggeman; Jeffrey L Lennox; Patricio E Ray; Robert C Kalayjian Journal: Clin Infect Dis Date: 2014-09-17 Impact factor: 9.079
Authors: Sherwin K B Sy; Ruben Malmberg; Aoi Matsushima; Eduardo Asin-Prieto; Bernd Rosenkranz; Mark F Cotton; Hartmut Derendorf; Steve Innes Journal: Int J Antimicrob Agents Date: 2015-01-19 Impact factor: 5.283
Authors: Murli Purswani; Kunjal Patel; Jeffrey B Kopp; George R Seage; Miriam C Chernoff; Rohan Hazra; George K Siberry; Lynne M Mofenson; Gwendolyn B Scott; Russell B Van Dyke Journal: Pediatr Infect Dis J Date: 2013-05 Impact factor: 2.129
Authors: Diana M Gibb; Hilda Kizito; Elizabeth C Russell; Ennie Chidziva; Eva Zalwango; Ruth Nalumenya; Moira Spyer; Dinah Tumukunde; Kusum Nathoo; Paula Munderi; Hope Kyomugisha; James Hakim; Heiner Grosskurth; Charles F Gilks; A Sarah Walker; Phillipa Musoke Journal: PLoS Med Date: 2012-05-15 Impact factor: 11.069
Authors: Ma Isabel de Jose; Santiago Jiménez de Ory; Maria Espiau; Claudia Fortuny; Ma Luisa Navarro; Pere Soler-Palacín; Ma Angeles Muñoz-Fernandez Journal: BMC Infect Dis Date: 2013-01-02 Impact factor: 3.090