| Literature DB >> 21075743 |
Paulo C Carvalho1, Juliana S G Fischer, Jonas Perales, John R Yates, Valmir C Barbosa, Elias Bareinboim.
Abstract
SUMMARY: We present an approach to statistically pinpoint differentially expressed proteins that have quantitation values near the quantitation threshold and are not identified in all replicates (marginal cases). Our method uses a Bayesian strategy to combine parametric statistics with an empirical distribution built from the reproducibility quality of the technical replicates. AVAILABILITY: The software is freely available for academic use at http://pcarvalho.com/patternlab.Mesh:
Substances:
Year: 2010 PMID: 21075743 PMCID: PMC3018820 DOI: 10.1093/bioinformatics/btq632
Source DB: PubMed Journal: Bioinformatics ISSN: 1367-4803 Impact factor: 6.937