Literature DB >> 21075176

Protective effect of flavonoids from Astragalus complanatus on radiation induced damages in mice.

Lin Qi1, Chun-Yu Liu, Wen-Qian Wu, Zhen-Lun Gu, Ci-Yi Guo.   

Abstract

This study aimed to evaluate the radioprotective effect of flavonoids extracted from the seeds of Astragalus complanatus R.Br. (FAC) and their protective mechanism against radiation damage. FAC increased the survival rate of mice and made the damaged organ injured by (60)Co γ-irradiation recovered to normal appearance with the mechanism of enhancing immune function and blood-producing function in vivo. The molecule mechanism of FAC against radiation is involved in the reduction of DNA injury and mutation in vitro. Eleven monomers of the FAC were analyzed by HPLC. These results seem to support the use of FAC in relieving radiation damage.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 21075176     DOI： 10.1016/j.fitote.2010.11.015

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  10 in total

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Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2015-04-24       Impact factor: 3.000

2.  Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation.

Authors:  Shin Bi Oh; Hee Ra Park; Young Jung Jang; Seon Young Choi; Tae Gen Son; Jaewon Lee
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4.  Synergistic radiation protective effect of purified Auricularia auricular-judae polysaccharide (AAP IV) with grape seed procyanidins.

Authors:  Haina Bai; Zhenyu Wang; Jie Cui; Keli Yun; Hua Zhang; Rui Hai Liu; Ziluan Fan; Cuilin Cheng
Journal:  Molecules       Date:  2014-12-11       Impact factor: 4.411

5.  Effects of astragalus injection on different stages of early hepatocarcinogenesis in a two-stage hepatocarcinogenesis model using rats.

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6.  Flavonol glycoside complanatoside A requires FOXO/DAF-16, NRF2/SKN-1, and HSF-1 to improve stress resistances and extend the life span of Caenorhabditis elegans.

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7.  Protective effect of anthocyanin from Lonicera Caerulea var. Edulis on radiation-induced damage in mice.

Authors:  Haitian Zhao; Zhenyu Wang; Fengming Ma; Xin Yang; Cuilin Cheng; Lei Yao
Journal:  Int J Mol Sci       Date:  2012-09-18       Impact factor: 6.208

Review 8.  Flavonoids from the Genus Astragalus: Phytochemistry and Biological Activity.

Authors:  Viktor M Bratkov; Aleksandar M Shkondrov; Petranka K Zdraveva; Ilina N Krasteva
Journal:  Pharmacogn Rev       Date:  2016 Jan-Jun

9.  Protective Effects on 60Co-γ Radiation Damage of Pine Cone Polyphenols from Pinus koraiensis-Loaded Chitosan Microspheres In Vivo.

Authors:  Sujuan Shao; Juanjuan Yi; Joe M Regenstein; Cuilin Cheng; Hua Zhang; Haitian Zhao; Zhenyu Wang
Journal:  Molecules       Date:  2018-06-08       Impact factor: 4.411

10.  Bioactive Flavonoid Glycosides and HPLC and UPLC Quantification of Commercial Astragali Complanati Semen.

Authors:  Jenny Chun-Ling Kuo; Li-Jie Zhang; Hung-Tse Huang; Chia-Ching Liaw; Zhi-Hu Lin; Min Liu; Yao-Haur Kuo
Journal:  Molecules       Date:  2020-10-16       Impact factor: 4.927
  10 in total

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