David B Seifer1, Valerie L Baker, Benjamin Leader. 1. Maimonides Medical Center, Department of Obstetrics and Gynecology, Genesis Fertility and Reproductive Medicine, Brooklyn, New York, USA. drseifer@genesisfertility.com
Abstract
OBJECTIVE: To determine age-specific serum anti-Müllerian hormone (AMH) values for women presenting to U.S. fertility clinics. DESIGN: Retrospective study. SETTING: Single clinical reference laboratory. PATIENT(S): A total of 17,120 women of reproductive age ranging from 24 to 50 years old. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Determination of single-year median and mean AMH values with SDs. RESULT(S): Single-year-specific median, mean, and SD values are summarized in Table 1. Both median and mean AMH values decreased steadily in a manner highly correlated with advancing age. The average yearly decrease in the median serum AMH value was 0.2 ng/mL/year through age 35 and then diminished to 0.1 ng/mL/year after age 35. The rate of decline in mean AMH values was 0.2 ng/mL/year through age 40 and then diminished to 0.1 ng/mL/year thereafter. CONCLUSION(S): Median and mean AMH levels decreased steadily with increasing age from 24 to 50 years of age. Such data may be of value to physicians and their patients who are considering reproductive options.
OBJECTIVE: To determine age-specific serum anti-Müllerian hormone (AMH) values for women presenting to U.S. fertility clinics. DESIGN: Retrospective study. SETTING: Single clinical reference laboratory. PATIENT(S): A total of 17,120 women of reproductive age ranging from 24 to 50 years old. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Determination of single-year median and mean AMH values with SDs. RESULT(S): Single-year-specific median, mean, and SD values are summarized in Table 1. Both median and mean AMH values decreased steadily in a manner highly correlated with advancing age. The average yearly decrease in the median serum AMH value was 0.2 ng/mL/year through age 35 and then diminished to 0.1 ng/mL/year after age 35. The rate of decline in mean AMH values was 0.2 ng/mL/year through age 40 and then diminished to 0.1 ng/mL/year thereafter. CONCLUSION(S): Median and mean AMH levels decreased steadily with increasing age from 24 to 50 years of age. Such data may be of value to physicians and their patients who are considering reproductive options.
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