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Literature DB >> 21074711

Targeting p21 degradation locally.

Abstract

Just as the activity of many multifunctional proteins is restricted by subcellular localization, so is their regulation. In this issue of Development Cell, Starostina et al. identify an E3 ubiquitin ligase, CRL2(LRR1), for the cyclin-dependent kinase inhibitor p21 that specifically ubiquitylates cytoplasmic p21 to facilitate cell migration.

Entities: Disease Gene Species

Year: 2010 PMID： 21074711 PMCID： PMC4877684 DOI： 10.1016/j.devcel.2010.10.020

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

10 in total

1. CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.

Authors: Natalia G Starostina; Jennifer M Simpliciano; Michael A McGuirk; Edward T Kipreos
Journal: Dev Cell Date: 2010-11-16 Impact factor: 12.270

2. APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase.

Authors: Virginia Amador; Sheng Ge; Patricia G Santamaría; Daniele Guardavaccaro; Michele Pagano
Journal: Mol Cell Date: 2007-08-03 Impact factor: 17.970

3. CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.

Authors: Hideo Nishitani; Yasushi Shiomi; Hiroka Iida; Masato Michishita; Toshihiro Takami; Toshiki Tsurimoto
Journal: J Biol Chem Date: 2008-08-14 Impact factor: 5.157

2 in total

1. X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression.

Authors: Tadashi Nakagawa; Yue Xiong
Journal: Mol Cell Date: 2011-08-05 Impact factor: 17.970

2. Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation.

Authors: Nina-Naomi Kreis; Alexandra Friemel; Brigitte Zimmer; Susanne Roth; Michael A Rieger; Udo Rolle; Frank Louwen; Juping Yuan
Journal: Oncotarget Date: 2016-08-02

2 in total

Targeting p21 degradation locally.

1. CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells.

2. APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase.

3. CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.

4. CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans.

5. Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins.

6. Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection.

Review 7. Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?

8. Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase.

9. The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.

10. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

1. X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression.

2. Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation.