Literature DB >> 21074581

Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis.

Mary Morada1, Ondrej Smid, Vladimir Hampl, Robert Sutak, Brian Lam, Paola Rappelli, Daniele Dessì, Pier L Fiori, Jan Tachezy, Nigel Yarlett.   

Abstract

The arginine dihydrolase (ADH) pathway has an analogous function to the urea cycle in mitochondria-containing cells, by removing nitrogen from amino acids and generating ATP. Subcellular localization of the ADH pathway enzymes in Trichomonas vaginalis revealed that arginine deiminase (ADI) localizes to the hydrogenosome, a mitochondrion-like organelle of anaerobic protists. However the other enzymes of the ADH pathway, ornithine carbamyltransferase and carbamate kinase localize to the cytosol. Three gene sequences of T. vaginalis ADI (ADI 1-3) were identified in the T. vaginalis genome, all having putative mitochondrial targeting sequences. The ADI sequences were cloned and used to probe T. vaginalis using a carboxyterminal di-hemogglutinin epitope tag which demonstrated co-localization with malic enzyme confirming the hydrogenosome localization of this enzyme. Copyright Â
© 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 21074581      PMCID： PMC3026898          DOI： 10.1016/j.molbiopara.2010.10.004

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  17 in total

1.  Evolution of arginine deiminase (ADI) pathway genes.

Authors:  Manuel Zúñiga; Gaspar Pérez; Fernando González-Candelas
Journal:  Mol Phylogenet Evol       Date:  2002-12       Impact factor: 4.286

2.  Mitochondrial-type assembly of FeS centers in the hydrogenosomes of the amitochondriate eukaryote Trichomonas vaginalis.

Authors:  Robert Sutak; Pavel Dolezal; Heather L Fiumera; Ivan Hrdy; Andrew Dancis; Maria Delgadillo-Correa; Patricia J Johnson; Miklós Müller; Jan Tachezy
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-29       Impact factor: 11.205

3.  The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.

Authors:  J D Thompson; T J Gibson; F Plewniak; F Jeanmougin; D G Higgins
Journal:  Nucleic Acids Res       Date:  1997-12-15       Impact factor: 16.971

4.  Nitroimidazole and oxygen derived radicals detected by electron spin resonance in hydrogenosomal and cytosolic fractions from Trichomonas vaginalis.

Authors:  N Yarlett; C C Rowlands; J C Evans; N C Yarlett; D Lloyd
Journal:  Mol Biochem Parasitol       Date:  1987-07       Impact factor: 1.759

5.  Iron-ascorbate cleavable malic enzyme from hydrogenosomes of Trichomonas vaginalis: purification and characterization.

Authors:  T Drmota; P Proost; M Van Ranst; F Weyda; J Kulda; J Tachezy
Journal:  Mol Biochem Parasitol       Date:  1996-12-20       Impact factor: 1.759

6.  The contribution of the arginine dihydrolase pathway to energy metabolism by Trichomonas vaginalis.

Authors:  N Yarlett; M P Martinez; M A Moharrami; J Tachezy
Journal:  Mol Biochem Parasitol       Date:  1996-06       Impact factor: 1.759

7.  Arginine deiminase of Mycoplasma hominis: cytoplasmic and membrane-associated forms.

Authors:  J S Lin
Journal:  J Gen Microbiol       Date:  1986-06

8.  Euglena gracilis rhodoquinone:ubiquinone ratio and mitochondrial proteome differ under aerobic and anaerobic conditions.

Authors:  Meike Hoffmeister; Anita van der Klei; Carmen Rotte; Koen W A van Grinsven; Jaap J van Hellemond; Katrin Henze; Aloysius G M Tielens; William Martin
Journal:  J Biol Chem       Date:  2004-03-10       Impact factor: 5.157

9.  Crystal structures of arginine deiminase with covalent reaction intermediates; implications for catalytic mechanism.

Authors:  Kalyan Das; Gary H Butler; Victoria Kwiatkowski; Arthur D Clark; Prem Yadav; Eddy Arnold
Journal:  Structure       Date:  2004-04       Impact factor: 5.006

10.  Subcellular localization of the enzymes of the arginine dihydrolase pathway in Trichomonas vaginalis and Tritrichomonas foetus.

Authors:  N Yarlett; D G Lindmark; B Goldberg; M A Moharrami; C J Bacchi
Journal:  J Eukaryot Microbiol       Date:  1994 Nov-Dec       Impact factor: 3.346
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  12 in total

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Authors:  Vladimir Hampl; Courtney W Stairs; Andrew J Roger
Journal:  Mob Genet Elements       Date:  2011-05

Review 2.  Biochemistry and evolution of anaerobic energy metabolism in eukaryotes.

Authors:  Miklós Müller; Marek Mentel; Jaap J van Hellemond; Katrin Henze; Christian Woehle; Sven B Gould; Re-Young Yu; Mark van der Giezen; Aloysius G M Tielens; William F Martin
Journal:  Microbiol Mol Biol Rev       Date:  2012-06       Impact factor: 11.056

Review 3.  Diversity and origins of anaerobic metabolism in mitochondria and related organelles.

Authors:  Courtney W Stairs; Michelle M Leger; Andrew J Roger
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-09-26       Impact factor: 6.237

Review 4.  The Physiology of Phagocytosis in the Context of Mitochondrial Origin.

Authors:  William F Martin; Aloysius G M Tielens; Marek Mentel; Sriram G Garg; Sven B Gould
Journal:  Microbiol Mol Biol Rev       Date:  2017-06-14       Impact factor: 11.056

5.  Proteomic profile approach of effect of putrescine depletion over Trichomonas vaginalis.

Authors:  María Elizbeth Alvarez-Sánchez; Laura Itzel Quintas-Granados; Laura Isabel Vázquez-Carrillo; Jonathan Puente-Rivera; Alma Villalobos-Osnaya; María Dolores Ponce-Regalado; Minerva Camacho-Nuez
Journal:  Parasitol Res       Date:  2018-03-07       Impact factor: 2.289

6.  Transcriptomic identification of iron-regulated and iron-independent gene copies within the heavily duplicated Trichomonas vaginalis genome.

Authors:  Lenka Horváthová; Lucie Šafaríková; Marek Basler; Ivan Hrdy; Neritza B Campo; Jyh-Wei Shin; Kuo-Yang Huang; Po-Jung Huang; Rose Lin; Petrus Tang; Jan Tachezy
Journal:  Genome Biol Evol       Date:  2012-09-12       Impact factor: 3.416

7.  The core components of organelle biogenesis and membrane transport in the hydrogenosomes of Trichomonas vaginalis.

Authors:  Petr Rada; Pavel Doležal; Petr L Jedelský; Dejan Bursac; Andrew J Perry; Miroslava Šedinová; Kateřina Smíšková; Marian Novotný; Neritza Campo Beltrán; Ivan Hrdý; Trevor Lithgow; Jan Tachezy
Journal:  PLoS One       Date:  2011-09-15       Impact factor: 3.240

Review 8.  Recent Advances in the Trichomonas vaginalis Field.

Authors:  David Leitsch
Journal:  F1000Res       Date:  2016-02-11

9.  The mitochondrion-like organelle of Trimastix pyriformis contains the complete glycine cleavage system.

Authors:  Zuzana Zubáčová; Lukáš Novák; Jitka Bublíková; Vojtěch Vacek; Jan Fousek; Jakub Rídl; Jan Tachezy; Pavel Doležal; Cestmír Vlček; Vladimír Hampl
Journal:  PLoS One       Date:  2013-03-13       Impact factor: 3.240

10.  Symbiotic Association with Mycoplasma hominis Can Influence Growth Rate, ATP Production, Cytolysis and Inflammatory Response of Trichomonas vaginalis.

Authors:  Valentina Margarita; Paola Rappelli; Daniele Dessì; Gianfranco Pintus; Robert P Hirt; Pier L Fiori
Journal:  Front Microbiol       Date:  2016-06-20       Impact factor: 5.640
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