Literature DB >> 21074431

Design and synthesis of harzialactone analogues: promising anticancer agents.

Vishwas U Pawar1, Sougata Ghosh, Balu A Chopade, Vaishali S Shinde.   

Abstract

New homologues of harzialactone were synthesized using D-glucose as chiral template. Wittig reaction to introduce aromatic moiety in 10 and chemoselective anomeric oxidation of 13 were used as key reactions in our synthesis. Anticancer activity of these target molecules was assessed against five cancer cell lines, P388D1, HL60, COLO-205, Zr-75-1 and HeLa. Both compound 5 and 6, showed significant activity against colon cancer (COLO-205) and cervical cancer (HeLa) and moderate with others. To the best of our knowledge, this is the first report of harzialactone analogues as potent inhibitors of human colon and cervical cancer.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 21074431     DOI： 10.1016/j.bmcl.2010.10.100

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors.

Authors:  Sougata Ghosh; Mehul Ahire; Sumersing Patil; Amit Jabgunde; Meenakshi Bhat Dusane; Bimba N Joshi; Karishma Pardesi; Sanjay Jachak; Dilip D Dhavale; Balu A Chopade
Journal:  Evid Based Complement Alternat Med       Date:  2011-07-09       Impact factor: 2.629

2.  A simple, efficient synthesis of 2-aryl benzimidazoles using silica supported periodic Acid catalyst and evaluation of anticancer activity.

Authors:  Vyankat A Sontakke; Sougata Ghosh; Pravin P Lawande; Balu A Chopade; Vaishali S Shinde
Journal:  ISRN Org Chem       Date:  2013-04-24

3.  Rapid efficient synthesis and characterization of silver, gold, and bimetallic nanoparticles from the medicinal plant Plumbago zeylanica and their application in biofilm control.

Authors:  Gayatri R Salunke; Sougata Ghosh; R J Santosh Kumar; Samiksha Khade; Priya Vashisth; Trupti Kale; Snehal Chopade; Vikas Pruthi; Gopal Kundu; Jayesh R Bellare; Balu A Chopade
Journal:  Int J Nanomedicine       Date:  2014-05-27

4.  Hybrid Chemoenzymatic Synthesis of C7 -Sugars for Molecular Evidence of in vivo Shikimate Pathway Inhibition.

Authors:  Pascal Rath; Johanna Rapp; Klaus Brilisauer; Marvin Braun; Üner Kolukisaoglu; Karl Forchhammer; Stephanie Grond
Journal:  Chembiochem       Date:  2022-05-23       Impact factor: 3.461

5.  Diosgenin from Dioscorea bulbifera: novel hit for treatment of type II diabetes mellitus with inhibitory activity against α-amylase and α-glucosidase.

Authors:  Sougata Ghosh; Piyush More; Abhishek Derle; Ajay B Patil; Pramod Markad; Adersh Asok; Navanath Kumbhar; Mahemud L Shaikh; Boppana Ramanamurthy; Vaishali S Shinde; Dilip D Dhavale; Balu A Chopade
Journal:  PLoS One       Date:  2014-09-12       Impact factor: 3.240
  5 in total

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