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Literature DB >> 21074040

Modeling Rett syndrome with stem cells.

Abstract

The discovery that somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) raised the exciting possibility of modeling diseases with patient-specific cells. Marchetto et al. (2010) now use iPSC technology to generate, characterize, and treat an in vitro model for the autism spectrum disorder Rett syndrome.

Entities: Chemical Disease Gene Species

Year: 2010 PMID： 21074040 PMCID： PMC3538362 DOI： 10.1016/j.cell.2010.10.037

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

10 in total

Review 1. Induced pluripotency: history, mechanisms, and applications.

Authors: Matthias Stadtfeld; Konrad Hochedlinger
Journal: Genes Dev Date: 2010-10-15 Impact factor: 11.361

2. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.

Authors: Maria C N Marchetto; Cassiano Carromeu; Allan Acab; Diana Yu; Gene W Yeo; Yangling Mu; Gong Chen; Fred H Gage; Alysson R Muotri
Journal: Cell Date: 2010-11-12 Impact factor: 41.582

3. Female human iPSCs retain an inactive X chromosome.

Authors: Jason Tchieu; Edward Kuoy; Mark H Chin; Hung Trinh; Michaela Patterson; Sean P Sherman; Otaren Aimiuwu; Anne Lindgren; Shahrad Hakimian; Jerome A Zack; Amander T Clark; April D Pyle; William E Lowry; Kathrin Plath
Journal: Cell Stem Cell Date: 2010-08-19 Impact factor: 24.633

4. MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number.

Authors: Hsiao-Tuan Chao; Huda Y Zoghbi; Christian Rosenmund
Journal: Neuron Date: 2007-10-04 Impact factor: 17.173

5. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice.

Authors: R Z Chen; S Akbarian; M Tudor; R Jaenisch
Journal: Nat Genet Date: 2001-03 Impact factor: 38.330

6. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome.

Authors: J Guy; B Hendrich; M Holmes; J E Martin; A Bird
Journal: Nat Genet Date: 2001-03 Impact factor: 38.330

7. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.

Authors: R E Amir; I B Van den Veyver; M Wan; C Q Tran; U Francke; H Y Zoghbi
Journal: Nat Genet Date: 1999-10 Impact factor: 38.330

Review 8. Rett syndrome: model of neurodevelopmental disorders.

Authors: Alan K Percy; Jane B Lane
Journal: J Child Neurol Date: 2005-09 Impact factor: 1.987

9. Reversal of neurological defects in a mouse model of Rett syndrome.

Authors: Jacky Guy; Jian Gan; Jim Selfridge; Stuart Cobb; Adrian Bird
Journal: Science Date: 2007-02-08 Impact factor: 47.728

10. Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice.

Authors: Daniela Tropea; Emanuela Giacometti; Nathan R Wilson; Caroline Beard; Cortina McCurry; Dong Dong Fu; Ruth Flannery; Rudolf Jaenisch; Mriganka Sur
Journal: Proc Natl Acad Sci U S A Date: 2009-02-10 Impact factor: 11.205

10 in total

8 in total

1. Developmental and functional nature of human iPSC derived motoneurons.

Authors: Marianne Stockmann; Leonhard Linta; Karl J Föhr; Anja Boeckers; Albert C Ludolph; Georges F Kuh; Patrick T Udvardi; Christian Proepper; Alexander Storch; Alexander Kleger; Stefan Liebau; Tobias M Boeckers
Journal: Stem Cell Rev Rep Date: 2013-08 Impact factor: 5.739

Modeling Rett syndrome with stem cells.

Review 1. Induced pluripotency: history, mechanisms, and applications.

2. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.

3. Female human iPSCs retain an inactive X chromosome.

4. MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number.

5. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice.

6. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome.

7. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.

Review 8. Rett syndrome: model of neurodevelopmental disorders.

9. Reversal of neurological defects in a mouse model of Rett syndrome.

10. Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice.

1. Developmental and functional nature of human iPSC derived motoneurons.

2. The specification of telencephalic glutamatergic neurons from human pluripotent stem cells.

Review 3. Glial progenitor cell-based treatment of the childhood leukodystrophies.

4. Tinkering with transcription factors uncovers plasticity of somatic cells.

5. Recapitulation of spinal motor neuron-specific disease phenotypes in a human cell model of spinal muscular atrophy.

Review 6. Modeling neurodevelopmental disorders using human pluripotent stem cells.

7. X-chromosome inactivation in rett syndrome human induced pluripotent stem cells.

Review 8. A Dishful of a Troubled Mind: Induced Pluripotent Stem Cells in Psychiatric Research.