Literature DB >> 21073870

Feedback regulation of Ras2 guanine nucleotide exchange factor (Ras2-GEF) activity of Cdc25p by Cdc25p phosphorylation in the yeast Saccharomyces cerevisiae.

Dong Jian1, Zhang Aili, Bai Xiaojia, Zhao Huansheng, Hu Yun.   

Abstract

Ras-GEF Cdc25p has been found to be hyperphosphorylated upon glucose addition. This work provides evidence indicating that PKA activity positively regulates the degree of Cdc25p phosphorylation, and that the intracellular association of Cdc25p and Ras2p is independent of PKA activity. In vitro experiments revealed that the Ras2-GEF activity of Cdc25p is inhibited by Cdc25p phosphorylation. These data suggest a negative feedback mechanism by which intracellular cAMP synthesis is inhibited by PKA through Cdc25p phosphorylation.
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 21073870     DOI： 10.1016/j.febslet.2010.11.006

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  The impact of genomic variation on protein phosphorylation states and regulatory networks.

Authors:  Jan Grossbach; Ludovic Gillet; Mathieu Clément-Ziza; Corinna L Schmalohr; Olga T Schubert; Maximilian Schütter; Julia S P Mawer; Christopher A Barnes; Isabell Bludau; Matthias Weith; Peter Tessarz; Martin Graef; Ruedi Aebersold; Andreas Beyer
Journal:  Mol Syst Biol       Date:  2022-05       Impact factor: 13.068

2.  The role of feedback control mechanisms on the establishment of oscillatory regimes in the Ras/cAMP/PKA pathway in S. cerevisiae.

Authors:  Daniela Besozzi; Paolo Cazzaniga; Dario Pescini; Giancarlo Mauri; Sonia Colombo; Enzo Martegani
Journal:  EURASIP J Bioinform Syst Biol       Date:  2012-07-20

3.  Model-guided optogenetic study of PKA signaling in budding yeast.

Authors:  Jacob Stewart-Ornstein; Susan Chen; Rajat Bhatnagar; Jonathan S Weissman; Hana El-Samad
Journal:  Mol Biol Cell       Date:  2016-11-09       Impact factor: 4.138

4.  Network inference reveals novel connections in pathways regulating growth and defense in the yeast salt response.

Authors:  Matthew E MacGilvray; Evgenia Shishkova; Deborah Chasman; Michael Place; Anthony Gitter; Joshua J Coon; Audrey P Gasch
Journal:  PLoS Comput Biol       Date:  2018-05-08       Impact factor: 4.475

5.  Rewired cellular signaling coordinates sugar and hypoxic responses for anaerobic xylose fermentation in yeast.

Authors:  Kevin S Myers; Nicholas M Riley; Matthew E MacGilvray; Trey K Sato; Mick McGee; Justin Heilberger; Joshua J Coon; Audrey P Gasch
Journal:  PLoS Genet       Date:  2019-03-11       Impact factor: 5.917

6.  Modeling and analysis of the macronutrient signaling network in budding yeast.

Authors:  Amogh P Jalihal; Pavel Kraikivski; T M Murali; John J Tyson
Journal:  Mol Biol Cell       Date:  2021-09-08       Impact factor: 4.138
  6 in total

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