Literature DB >> 21073335

Regulation of bone mass by serotonin: molecular biology and therapeutic implications.

Gerard Karsenty1, Vijay K Yadav.   

Abstract

The molecular elucidation of two human skeletal dysplasias revealed that they are caused by an increase or a decrease in the synthesis of serotonin by enterochromaffin cells of the gut. This observation revealed a novel and powerful endocrine means to regulate bone mass. Exploiting these findings in the pharmacological arena led to the demonstration that inhibiting synthesis of gut-derived serotonin could be an effective means to treat low-bone-mass diseases such as osteoporosis.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21073335     DOI： 10.1146/annurev-med-090710-133426

Source DB:  PubMed          Journal:  Annu Rev Med        ISSN： 0066-4219            Impact factor:   13.739


  25 in total

1.  Effect of food restriction and leptin supplementation on fetal programming in mice.

Authors:  Kathleen A Pennington; Jennifer L Harper; Ashley N Sigafoos; Lindsey M Beffa; Stephanie M Carleton; Charlotte L Phillips; Laura C Schulz
Journal:  Endocrinology       Date:  2012-07-09       Impact factor: 4.736

Review 2.  Influence of pre- and peri-natal nutrition on skeletal acquisition and maintenance.

Authors:  M J Devlin; M L Bouxsein
Journal:  Bone       Date:  2011-06-24       Impact factor: 4.398

Review 3.  Potential role for therapies targeting DKK1, LRP5, and serotonin in the treatment of osteoporosis.

Authors:  Wei Zhang; Matthew T Drake
Journal:  Curr Osteoporos Rep       Date:  2012-03       Impact factor: 5.096

Review 4.  Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications.

Authors:  Guo-Lin Chen; Gregory M Miller
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2012-03       Impact factor: 3.568

5.  Propranolol Attenuates Risperidone-Induced Trabecular Bone Loss in Female Mice.

Authors:  Katherine J Motyl; Victoria E DeMambro; Deborah Barlow; David Olshan; Kenichi Nagano; Roland Baron; Clifford J Rosen; Karen L Houseknecht
Journal:  Endocrinology       Date:  2015-04-08       Impact factor: 4.736

6.  Overexpression of gastric leptin precedes adipocyte leptin during high-fat diet and is linked to 5HT-containing enterochromaffin cells.

Authors:  J Le Beyec; A-L Pelletier; K Arapis; M Hourseau; F Cluzeaud; V Descatoire; R Ducroc; T Aparicio; F Joly; A Couvelard; J-P Marmuse; M Le Gall; A Bado
Journal:  Int J Obes (Lond)       Date:  2014-01-28       Impact factor: 5.095

7.  Dietary tryptophan manipulation reveals a central role for serotonin in the anabolic response of appendicular skeleton to physical activity in rats.

Authors:  Valeria Sibilia; Francesca Pagani; Elisa Dieci; Emanuela Mrak; Marcella Marchese; Guido Zarattini; Francesca Guidobono
Journal:  Endocrine       Date:  2013-04-26       Impact factor: 3.633

8.  The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease.

Authors:  G M G Lima; B J M Corazza; R M Moraes; F E de Oliveira; L D de Oliveira; G C N Franco; D S Perrien; F Elefteriou; A L Anbinder
Journal:  J Periodontal Res       Date:  2016-01-06       Impact factor: 4.419

Review 9.  A dialogue between the immune system and brain, spoken in the language of serotonin.

Authors:  Nicole L Baganz; Randy D Blakely
Journal:  ACS Chem Neurosci       Date:  2012-12-07       Impact factor: 4.418

Review 10.  Skeletal integration of energy homeostasis: Translational implications.

Authors:  Beata Lecka-Czernik; Clifford J Rosen
Journal:  Bone       Date:  2015-07-23       Impact factor: 4.398
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.