Does low testosterone affect adaptive properties of adipose tissue in obese men?

Obesity and (pre)diabetes in males is associated with low serum testosterone and increased oestradiol levels. It is unknown whether these changes in sex steroids are part of a vicious circle resulting in an increase of risk for metabolic complications of obesity, or whether it presents merely an epiphenomenon. The risk for metabolic complications in obesity seems to be determined by adaptation and integrity of adipose tissue. It is unknown whether the typical changes in sex steroids seen in obese men are desirable or ominous with respect to these functions. However, it might be clinically relevant, as low serum testosterone can be treated, and well with different forms of interventional therapy. The present review provides a short summary on findings, obstacles and future research needed to gain better insight into consequences of changes in sex steroids for adaptation of adipose tissue in obese men.