J M Lucey1, P Gavin, M Cafferkey, K M Butler. 1. Department of Paediatrics, Children's University Hospital, Temple Street, Dublin 1, Ireland. Juliette.Lucey@health.wa.gov.au
Abstract
AIM: To document the long-term outcomes of pneumococcal meningitis in children presenting to a Dublin paediatric hospital in the pre-pneumococcal conjugate vaccine (PCV7) era (1998-2007). METHODS: Subjects with pneumococcal meningitis were identified at The Children's University Hospital, Dublin through the hospital surveillance system and laboratory archives. RESULTS: 44 children were identified with S. pneumoniae meningitis. Mean age of presentation was 23.45 months (2 days to 13 years) and 28 (65%) cases were less than 12 months old. Eight (18.6%) children died. 55% of cases were left with significant deficits. Of the survivors, 7 (20%) had moderate to severe neurological sequelae. CONCLUSION: Pneumococcal meningitis is a devastating childhood disease with significant mortality and morbidity, especially in those less than 2 years of age. These data provide a baseline against which the impact of PCV7 on pneumococcal meningitis can be measured.
AIM: To document the long-term outcomes of pneumococcal meningitis in children presenting to a Dublin paediatric hospital in the pre-pneumococcal conjugate vaccine (PCV7) era (1998-2007). METHODS: Subjects with pneumococcal meningitis were identified at The Children's University Hospital, Dublin through the hospital surveillance system and laboratory archives. RESULTS: 44 children were identified with S. pneumoniae meningitis. Mean age of presentation was 23.45 months (2 days to 13 years) and 28 (65%) cases were less than 12 months old. Eight (18.6%) children died. 55% of cases were left with significant deficits. Of the survivors, 7 (20%) had moderate to severe neurological sequelae. CONCLUSION:Pneumococcal meningitis is a devastating childhood disease with significant mortality and morbidity, especially in those less than 2 years of age. These data provide a baseline against which the impact of PCV7 on pneumococcal meningitis can be measured.
Authors: Daniel A Scott; Steven F Komjathy; Branda T Hu; Sherryl Baker; Lois A Supan; Carol A Monahan; William Gruber; George R Siber; Stephen P Lockhart Journal: Vaccine Date: 2007-06-26 Impact factor: 3.641
Authors: M Arditi; E O Mason; J S Bradley; T Q Tan; W J Barson; G E Schutze; E R Wald; L B Givner; K S Kim; R Yogev; S L Kaplan Journal: Pediatrics Date: 1998-11 Impact factor: 7.124
Authors: Lauri A Hicks; Lee H Harrison; Brendan Flannery; James L Hadler; William Schaffner; Allen S Craig; Delois Jackson; Ann Thomas; Bernard Beall; Ruth Lynfield; Arthur Reingold; Monica M Farley; Cynthia G Whitney Journal: J Infect Dis Date: 2007-10-04 Impact factor: 5.226
Authors: Anne Perrocheau; Anne-Claire De Benoist; Caroline Six; Véronique Goulet; Bénédicte Decludt; Daniel Levy-Bruhl Journal: Ann Med Interne (Paris) Date: 2002-09