RATIONALE AND OBJECTIVE: Although loudness dependence of auditory evoked potentials (LDAEPs) had been suggested as a noninvasive measure of central serotonin functions, recent studies suggest that LDAEP may be modulated by multiple neuromodulatory systems, such as dopamine. Here, we explore the relationship between LDAEP and dopamine and serotonin in the level of monoamine transporter availability. METHODS: Forty-nine healthy volunteers received LDAEP and single-photon emission computed tomography (SPECT) using [(99m)Tc] TRODAT and [(123)I] ADAM to approximate the availability of dopamine transporters (DATs) and serotonin transporters (SERTs). RESULTS: LDAEP was found to be positively associated with DAT, after adjusting for age and gender, and the log-transformed slope of loudness dependence at Cz was negatively associated with SERT. CONCLUSION: Our findings provide further evidence for the possible involvement of dopamine and serotonins in the genesis of LDAEP.
RATIONALE AND OBJECTIVE: Although loudness dependence of auditory evoked potentials (LDAEPs) had been suggested as a noninvasive measure of central serotonin functions, recent studies suggest that LDAEP may be modulated by multiple neuromodulatory systems, such as dopamine. Here, we explore the relationship between LDAEP and dopamine and serotonin in the level of monoamine transporter availability. METHODS: Forty-nine healthy volunteers received LDAEP and single-photon emission computed tomography (SPECT) using [(99m)Tc] TRODAT and [(123)I] ADAM to approximate the availability of dopamine transporters (DATs) and serotonin transporters (SERTs). RESULTS: LDAEP was found to be positively associated with DAT, after adjusting for age and gender, and the log-transformed slope of loudness dependence at Cz was negatively associated with SERT. CONCLUSION: Our findings provide further evidence for the possible involvement of dopamine and serotonins in the genesis of LDAEP.
Authors: Ana M Catafau; Víctor Pérez; María M Penengo; Santiago Bullich; Mónica Danús; Dolors Puigdemont; Juan C Pascual; Iluminada Corripio; Jordi Llop; Javier Perich; Enric Alvarez Journal: J Nucl Med Date: 2005-08 Impact factor: 10.057
Authors: Barry V O'Neill; Rodney J Croft; Sumie Leung; Chris Oliver; K Luan Phan; Pradeep J Nathan Journal: Psychopharmacology (Berl) Date: 2007-07-24 Impact factor: 4.530
Authors: Rajapillai L I Pillai; Elizabeth A Bartlett; Mala R Ananth; Chencan Zhu; Jie Yang; Greg Hajcak; Ramin V Parsey; Christine DeLorenzo Journal: Neuroimage Date: 2020-03-10 Impact factor: 6.556
Authors: Louisa J. Steinberg; Mark D. Underwood; Mihran J. Bakalian; Suham A. Kassir; J. John Mann; Victoria Arango Journal: J Psychiatry Neurosci Date: 2019-09-01 Impact factor: 6.186