Literature DB >> 21072385

2-Oxoglutarate oxygenases are inhibited by a range of transition metals.

Rok Sekirnik1, Nathan R Rose, Jasmin Mecinović, Christopher J Schofield.   

Abstract

2-Oxoglutarate oxygenases are inhibited by a range of transition metals, as exemplified by studies on human histone demethylases and prolyl hydroxylase domain 2 (PHD2 or EGLN1). The biological effects associated with 2-oxoglutarate oxygenase inhibition may result from inhibition of more than one enzyme and by mechanisms in addition to simple competition with the Fe(ii) cofactor.

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Year:  2010        PMID： 21072385     DOI： 10.1039/c004952b

Source DB:  PubMed          Journal:  Metallomics        ISSN： 1756-5901            Impact factor:   4.526


  10 in total

1.  Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

Authors:  Nathan R Rose; Esther C Y Woon; Anthony Tumber; Louise J Walport; Rasheduzzaman Chowdhury; Xuan Shirley Li; Oliver N F King; Clarisse Lejeune; Stanley S Ng; Tobias Krojer; Mun Chiang Chan; Anna M Rydzik; Richard J Hopkinson; Ka Hing Che; Michelle Daniel; Claire Strain-Damerell; Carina Gileadi; Grazyna Kochan; Ivanhoe K H Leung; James Dunford; Kar Kheng Yeoh; Peter J Ratcliffe; Nicola Burgess-Brown; Frank von Delft; Susanne Muller; Brian Marsden; Paul E Brennan; Michael A McDonough; Udo Oppermann; Robert J Klose; Christopher J Schofield; Akane Kawamura
Journal:  J Med Chem       Date:  2012-07-11       Impact factor: 7.446

2.  Copper Inhibits the AlkB Family DNA Repair Enzymes under Wilson's Disease Condition.

Authors:  Ke Bian; Fangyi Chen; Zachary T Humulock; Qi Tang; Deyu Li
Journal:  Chem Res Toxicol       Date:  2017-09-26       Impact factor: 3.739

Review 3.  Mechanisms of nickel toxicity in microorganisms.

Authors:  Lee Macomber; Robert P Hausinger
Journal:  Metallomics       Date:  2011-07-28       Impact factor: 4.526

4.  Vulnerability of HIF1α and HIF2α to damage by proteotoxic stressors.

Authors:  Lauren M Meyers; Casey Krawic; Michal W Luczak; Anatoly Zhitkovich
Journal:  Toxicol Appl Pharmacol       Date:  2022-04-30       Impact factor: 4.460

5.  Quantitative analysis of histone demethylase probes using fluorescence polarization.

Authors:  Wenqing Xu; Jessica D Podoll; Xuan Dong; Anthony Tumber; Udo Oppermann; Xiang Wang
Journal:  J Med Chem       Date:  2013-06-13       Impact factor: 7.446

6.  Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Authors:  Armin Thalhammer; Jasmin Mecinović; Christoph Loenarz; Anthony Tumber; Nathan R Rose; Tom D Heightman; Christopher J Schofield
Journal:  Org Biomol Chem       Date:  2010-11-15       Impact factor: 3.876

7.  Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.

Authors:  Lennart Brewitz; Anthony Tumber; Inga Pfeffer; Michael A McDonough; Christopher J Schofield
Journal:  Sci Rep       Date:  2020-05-26       Impact factor: 4.379

8.  Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase.

Authors:  Xiangzhong Sun; Yaxin Li; Wenrong He; Chenggong Ji; Peixue Xia; Yichuan Wang; Shuo Du; Hongjiang Li; Natasha Raikhel; Junyu Xiao; Hongwei Guo
Journal:  Nat Commun       Date:  2017-06-12       Impact factor: 14.919

9.  Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases.

Authors:  Joanna Bonnici; Anthony Tumber; Akane Kawamura; Christopher J Schofield
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-06-05       Impact factor: 6.237

10.  Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

Authors:  Kar Kheng Yeoh; Mun Chiang Chan; Armin Thalhammer; Marina Demetriades; Rasheduzzaman Chowdhury; Ya-Min Tian; Ineke Stolze; Luke A McNeill; Myung Kyu Lee; Esther C Y Woon; Mukram M Mackeen; Akane Kawamura; Peter J Ratcliffe; Jasmin Mecinović; Christopher J Schofield
Journal:  Org Biomol Chem       Date:  2012-11-15       Impact factor: 3.876
  10 in total

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