Literature DB >> 21071835

Reduction of blood pressure by soybean saponins, renin inhibitors from soybean, in spontaneously hypertensive rats.

Kazuyuki Hiwatashi1, Hitoshi Shirakawa, Kazuyuki Hori, Yumiko Yoshiki, Nao Suzuki, Mika Hokari, Michio Komai, Saori Takahashi.   

Abstract

The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC(50)=59.9 µg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 21071835     DOI： 10.1271/bbb.100328

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  8 in total

1.  Kinetics of the inhibition of renin and angiotensin i converting enzyme by polar and non-polar polyphenolic extracts of Vernonia amygdalina and Gongronema latifolium leaves.

Authors:  Comfort F Ajibola; Afolabi F Eleyinmi; Rotimi E Aluko
Journal:  Plant Foods Hum Nutr       Date:  2011-11       Impact factor: 3.921

2.  Antiproliferative effect of ME3738, a derivative of soyasapogenol, on hepatocellular carcinoma cell lines in vitro and in vivo.

Authors:  Sachiko Ogasawara; Jun Akiba; Masamichi Nakayama; Hironori Kusano; Hirohisa Yano
Journal:  Biomed Rep       Date:  2016-10-25

3.  Inhibitory effect of soy saponins on the activity of β-lactamases, including New Delhi metallo-β-lactamase 1.

Authors:  Hitoshi Horie; Asuka Chiba; Shigeo Wada
Journal:  J Food Sci Technol       Date:  2018-03-05       Impact factor: 2.701

Review 4.  Three key proteases--angiotensin-I-converting enzyme (ACE), ACE2 and renin--within and beyond the renin-angiotensin system.

Authors:  Cuie Guang; Robert D Phillips; Bo Jiang; Franco Milani
Journal:  Arch Cardiovasc Dis       Date:  2012-06-15       Impact factor: 2.340

5.  Inhibitory Activities of Polyphenolic Extracts of Bangladeshi Vegetables against α-Amylase, α-Glucosidase, Pancreatic Lipase, Renin, and Angiotensin-Converting Enzyme.

Authors:  Razia Sultana; Adeola M Alashi; Khaleda Islam; Md Saifullah; C Emdad Haque; Rotimi E Aluko
Journal:  Foods       Date:  2020-06-29

6.  Methanol (80%) leaf extract of Otostegia integrifolia Benth (Lamiaceae) lowers blood pressure in rats through interference with calcium conductance.

Authors:  Abel Degu; Abiy Abebe; Ephrem Engidawork
Journal:  BMC Complement Med Ther       Date:  2021-02-04

7.  Multiple organ failure leading to death after ingestion of Caltha palustris: A case report.

Authors:  Keun Taek Lee; Won Young Sung
Journal:  Medicine (Baltimore)       Date:  2021-11-19       Impact factor: 1.889

8.  Anti-glaucoma potential of Heliotropium indicum Linn in experimentally-induced glaucoma.

Authors:  Samuel Kyei; George Asumeng Koffuor; Paul Ramkissoon; Osei Owusu-Afriyie
Journal:  Eye Vis (Lond)       Date:  2015-10-01
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.