Literature DB >> 21071476

Selective estrogen receptor modulators as brain therapeutic agents.

María Angeles Arevalo1, María Santos-Galindo, Natalia Lagunas, Iñigo Azcoitia, Luis M Garcia-Segura.   

Abstract

Selective estrogen receptor modulators (SERMs), used for the treatment of breast cancer, osteoporosis, and menopausal symptoms, affect the nervous system. Some SERMs trigger neuroprotective mechanisms and reduce neural damage in different experimental models of neural trauma, brain inflammation, neurodegenerative diseases, cognitive impairment, and affective disorders. New SERMs with specific actions on neurons and glial cells may represent promising therapeutic tools for the brain.

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Year:  2011        PMID： 21071476     DOI： 10.1677/JME-10-0122

Source DB:  PubMed          Journal:  J Mol Endocrinol        ISSN： 0952-5041            Impact factor:   5.098


  35 in total

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10.  Selective estrogen receptor modulators (SERMs) enhance neurogenesis and spine density following focal cerebral ischemia.

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Journal:  J Steroid Biochem Mol Biol       Date:  2014-05-09       Impact factor: 4.292
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