OBJECTIVES: To identify predictors of conversion to definite multiple sclerosis (MS) in patients with a cord clinically isolated syndrome. METHODS: The predictive values for conversion to MS of clinical, magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) variables in 114 patients with acute partial myelitis confirmed by a spinal cord lesion on MRI were studied. Other causes of cord syndromes were excluded. RESULTS: MS was diagnosed in 78 patients (86%) during 4.0 ± 1.9 years of follow-up. Some 67 of these patients had a second clinical episode. The diagnosis of isolated myelitis was maintained for 36 patients, 78% of whom (28 cases) were followed for at least 2 years, comparable to the MS patients. Age, bladder involvement, ≥ 2 cord lesions on MRI, ≥ 9 brain lesions, ≥ 3 periventricular lesions and intrathecal IgG synthesis predicted conversion to clinically definite MS. Multivariate logistic analysis identified three predictors of MS diagnosis: age ≤ 40 years, inflammatory CSF and ≥ 3 periventricular lesions on brain MRI. CONCLUSION: Two out of three baseline factors (age, periventricular lesions and inflammatory CSF) predicted conversion to MS with better accuracy than the revised McDonald criteria for dissemination in space.
OBJECTIVES: To identify predictors of conversion to definite multiple sclerosis (MS) in patients with a cord clinically isolated syndrome. METHODS: The predictive values for conversion to MS of clinical, magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) variables in 114 patients with acute partial myelitis confirmed by a spinal cord lesion on MRI were studied. Other causes of cord syndromes were excluded. RESULTS: MS was diagnosed in 78 patients (86%) during 4.0 ± 1.9 years of follow-up. Some 67 of these patients had a second clinical episode. The diagnosis of isolated myelitis was maintained for 36 patients, 78% of whom (28 cases) were followed for at least 2 years, comparable to the MS patients. Age, bladder involvement, ≥ 2 cord lesions on MRI, ≥ 9 brain lesions, ≥ 3 periventricular lesions and intrathecal IgG synthesis predicted conversion to clinically definite MS. Multivariate logistic analysis identified three predictors of MS diagnosis: age ≤ 40 years, inflammatory CSF and ≥ 3 periventricular lesions on brain MRI. CONCLUSION: Two out of three baseline factors (age, periventricular lesions and inflammatory CSF) predicted conversion to MS with better accuracy than the revised McDonald criteria for dissemination in space.
Authors: Wallace J Brownlee; Josephine K Swanton; Katherine A Miszkiel; David H Miller; Olga Ciccarelli Journal: Neurology Date: 2016-07-15 Impact factor: 9.910
Authors: V Wottschel; D C Alexander; P P Kwok; D T Chard; M L Stromillo; N De Stefano; A J Thompson; D H Miller; O Ciccarelli Journal: Neuroimage Clin Date: 2014-12-04 Impact factor: 4.881
Authors: Massimo Filippi; Maria A Rocca; Olga Ciccarelli; Nicola De Stefano; Nikos Evangelou; Ludwig Kappos; Alex Rovira; Jaume Sastre-Garriga; Mar Tintorè; Jette L Frederiksen; Claudio Gasperini; Jacqueline Palace; Daniel S Reich; Brenda Banwell; Xavier Montalban; Frederik Barkhof Journal: Lancet Neurol Date: 2016-01-26 Impact factor: 44.182
Authors: Marco Battaglini; Hugo Vrenken; Riccardo Tappa Brocci; Giordano Gentile; Ludovico Luchetti; Adriaan Versteeg; Mark S Freedman; Bernard M J Uitdehaag; Ludwig Kappos; Giancarlo Comi; Andrea Seitzinger; Dominic Jack; Maria Pia Sormani; Frederik Barkhof; Nicola De Stefano Journal: Eur J Neurol Date: 2022-04-04 Impact factor: 6.288