Literature DB >> 21071441

Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.

Yo Sasaki1, Jeffrey Milbrandt.   

Abstract

Axonal degeneration is an early and important component of many neurological disorders. Overexpression of nicotinamide mononucleotide adenylyltransferase (Nmnat), a component of the slow Wallerian degeneration (Wld(s)) protein, protects axons from a variety of insults. We found that transduction of Nmnat protein into severed axons via virus-like particles prevented axonal degeneration. The post-injury efficacy of Nmnat indicates that its protective effects occur locally within the axon and provides an opportunity to develop novel agents to treat axonal damage.

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Year:  2010        PMID： 21071441      PMCID： PMC3009846          DOI： 10.1074/jbc.C110.193904

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  18 in total

Review 1.  Axonal self-destruction and neurodegeneration.

Authors:  Martin C Raff; Alan V Whitmore; John T Finn
Journal:  Science       Date:  2002-05-03       Impact factor: 47.728

2.  The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus. I. Analysis of neutralizing epitopes with monoclonal antibodies.

Authors:  L Lefrancois; D S Lyles
Journal:  Virology       Date:  1982-08       Impact factor: 3.616

3.  Enhanced gene transfer with fusogenic liposomes containing vesicular stomatitis virus G glycoprotein.

Authors:  A Abe; A Miyanohara; T Friedmann
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

4.  Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy.

Authors:  Yo Sasaki; Toshiyuki Araki; Jeffrey Milbrandt
Journal:  J Neurosci       Date:  2006-08-16       Impact factor: 6.167

5.  Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors.

Authors:  Carlos Lois; Elizabeth J Hong; Shirley Pease; Eric J Brown; David Baltimore
Journal:  Science       Date:  2002-01-10       Impact factor: 47.728

6.  Critical factors influencing stable transduction of human CD34(+) cells with HIV-1-derived lentiviral vectors.

Authors:  D L Haas; S S Case; G M Crooks; D B Kohn
Journal:  Mol Ther       Date:  2000-07       Impact factor: 11.454

7.  Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.

Authors:  T G Mack; M Reiner; B Beirowski; W Mi; M Emanuelli; D Wagner; D Thomson; T Gillingwater; F Court; L Conforti; F S Fernando; A Tarlton; C Andressen; K Addicks; G Magni; R R Ribchester; V H Perry; M P Coleman
Journal:  Nat Neurosci       Date:  2001-12       Impact factor: 24.884

8.  A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration.

Authors:  Bradley R Miller; Craig Press; Richard W Daniels; Yo Sasaki; Jeffrey Milbrandt; Aaron DiAntonio
Journal:  Nat Neurosci       Date:  2009-03-15       Impact factor: 24.884

9.  Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide.

Authors:  Yo Sasaki; Bhupinder P S Vohra; Frances E Lund; Jeffrey Milbrandt
Journal:  J Neurosci       Date:  2009-04-29       Impact factor: 6.167

10.  Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.

Authors:  Naoki Yahata; Shigeki Yuasa; Toshiyuki Araki
Journal:  J Neurosci       Date:  2009-05-13       Impact factor: 6.167
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  40 in total

Review 1.  Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.

Authors:  Josiah Gerdts; Daniel W Summers; Jeffrey Milbrandt; Aaron DiAntonio
Journal:  Neuron       Date:  2016-02-03       Impact factor: 17.173

Review 2.  Emergence of SARM1 as a Potential Therapeutic Target for Wallerian-type Diseases.

Authors:  Heather S Loring; Paul R Thompson
Journal:  Cell Chem Biol       Date:  2019-11-21       Impact factor: 8.116

3.  SARM1 activation triggers axon degeneration locally via NAD⁺ destruction.

Authors:  Josiah Gerdts; E J Brace; Yo Sasaki; Aaron DiAntonio; Jeffrey Milbrandt
Journal:  Science       Date:  2015-04-23       Impact factor: 47.728

4.  WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering.

Authors:  Michelle A Avery; Timothy M Rooney; Jignesh D Pandya; Thomas M Wishart; Thomas H Gillingwater; James W Geddes; Patrick G Sullivan; Marc R Freeman
Journal:  Curr Biol       Date:  2012-03-15       Impact factor: 10.834

5.  Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s).

Authors:  Michael S Cohen; Ananda K Ghosh; Hyung Joon Kim; Noo Li Jeon; Samie R Jaffrey
Journal:  Chem Biol       Date:  2012-02-24

Review 6.  Diverse cellular and molecular modes of axon degeneration.

Authors:  Lukas J Neukomm; Marc R Freeman
Journal:  Trends Cell Biol       Date:  2014-04-27       Impact factor: 20.808

Review 7.  Signaling mechanisms regulating Wallerian degeneration.

Authors:  Marc R Freeman
Journal:  Curr Opin Neurobiol       Date:  2014-06-05       Impact factor: 6.627

8.  Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death.

Authors:  Philip B Verghese; Yo Sasaki; Donghan Yang; Floy Stewart; Fatima Sabar; Mary Beth Finn; Christine M Wroge; Steven Mennerick; Jeffrey J Neil; Jeffrey Milbrandt; David M Holtzman
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-04       Impact factor: 11.205

9.  Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration.

Authors:  Robert K Koenekoop; Hui Wang; Jacek Majewski; Xia Wang; Irma Lopez; Huanan Ren; Yiyun Chen; Yumei Li; Gerald A Fishman; Mohammed Genead; Jeremy Schwartzentruber; Naimesh Solanki; Elias I Traboulsi; Jingliang Cheng; Clare V Logan; Martin McKibbin; Bruce E Hayward; David A Parry; Colin A Johnson; Mohammed Nageeb; James A Poulter; Moin D Mohamed; Hussain Jafri; Yasmin Rashid; Graham R Taylor; Vafa Keser; Graeme Mardon; Huidan Xu; Chris F Inglehearn; Qing Fu; Carmel Toomes; Rui Chen
Journal:  Nat Genet       Date:  2012-07-29       Impact factor: 38.330

Review 10.  Feeding the brain and nurturing the mind: Linking nutrition and the gut microbiota to brain development.

Authors:  Manu S Goyal; Siddarth Venkatesh; Jeffrey Milbrandt; Jeffrey I Gordon; Marcus E Raichle
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-17       Impact factor: 11.205
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