Literature DB >> 2107086

Effect of interferon-gamma and tumor necrosis factor-alpha on lymphoepithelial interactions within thymic nurse cells.

M P Defresne1, C Humblet, A M Rongy, R Greimers, J Boniver.   

Abstract

Isolated thymic nurse cells (TNC) represent a specialized microenvironment in vivo where thymocytes interact specifically with subcapsular epithelial cells. They are thought to play a critical role in the process of T cell differentiation. We demonstrate that recombinant murine interferon-gamma and recombinant human tumor necrosis factor-alpha can act on these interactions: they stimulate TNC-derived epithelial cells to establish interactions with thymocytes in vitro and to form new lymphoepithelial complexes. This phenomenon is partially inhibited by anti-Ia monoclonal antibodies. Implications of these findings for normal intrathymic differentiation are discussed.

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Year:  1990        PMID： 2107086     DOI： 10.1002/eji.1830200229

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  6 in total

Review 1.  Questionable thymic nurse cell.

Authors:  M Pezzano; M Samms; M Martinez; J Guyden
Journal:  Microbiol Mol Biol Rev       Date:  2001-09       Impact factor: 11.056

2.  The ER-TR4 monoclonal antibody recognizes murine thymic epithelial cells (type 1) and inhibits their capacity to interact with immature thymocytes: immuno-electron microscopic and functional studies.

Authors:  M P Defresne; B Nabarra; E van Vliet; R Willemsen; H van Dongen; W van Ewijk
Journal:  Histochemistry       Date:  1994-06

3.  Differential effect of tumour necrosis factor on human thymocyte subpopulations.

Authors:  M A Muñoz-Fernández; F X Pimentel-Muiños; A González; F Gambon; L Alvarez-Vallina; M Fresno
Journal:  Immunology       Date:  1992-07       Impact factor: 7.397

4.  High tumor necrosis factor alpha (TNF-alpha) production in Trypanosoma cruzi-infected pregnant mice and increased TNF-alpha gene transcription in their offspring.

Authors:  M T Rivera; S Marques de Araujo; R Lucas; J Deman; C Truyens; M P Defresne; P de Baetselier; Y Carlier
Journal:  Infect Immun       Date:  1995-02       Impact factor: 3.441

5.  Adhesion molecules involved in the binding and subsequent engulfment of thymocytes by a rat thymic epithelial cell line.

Authors:  M Colić; D Vucević; M Miyasaka; T Tamatani; M D Pavlović; A Dujić
Journal:  Immunology       Date:  1994-11       Impact factor: 7.397

6.  Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

Authors:  X D Yang; R Tisch; S M Singer; Z A Cao; R S Liblau; R D Schreiber; H O McDevitt
Journal:  J Exp Med       Date:  1994-09-01       Impact factor: 14.307
  6 in total

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