BACKGROUND AND AIM: Previous studies have demonstrated that endogenous bone morphogenic protein-7 (BMP-7) level is reduced in acute kidney injury and administration of exogenous BMP-7 has a beneficial effect on kidney function. In spite of preventive management, contrast-induced nephropathy (CIN) is still the third cause of acute deterioration of kidney function in hospitalized patients. With this background in mind, we studied changes in serum BMP-7 in a group of patients with chronic kidney disease and contrast-induced nephropathy. MATERIALS AND METHODS: We enrolled 45 consecutive adult patients with a baseline serum creatinine ≥ 1.4 mg/dl admitted for coronary angiography. We measured serum BMP-7 levels before and 48 h after coronary angiography. The primary end point was the development of CIN, defined as an increase in serum creatinine concentration by 0.25 mg/dl or 25% over the baseline value within 72 h from contrast exposure. RESULTS: Overall, CIN occurred in 8 (17%) patients. The concentrations of serum BMP-7 were significantly decreased in the CIN group compared to baseline (488.6 ± 56.8 vs. 356.4 ± 24.8, P = 0.01); in contrast, the concentration of BMP-7 level did not change in patients without CIN (444.6 ± 54.6 vs. 440.0 ± 53.9, P = 0.09). CONCLUSION: BMP-7 level significantly decreases in patients who develop CIN after coronary angiography. Therefore, BMP-7 might be a diagnostic biomarker for CIN and a possibly promising agent for the treatment of CIN.
BACKGROUND AND AIM: Previous studies have demonstrated that endogenous bone morphogenic protein-7 (BMP-7) level is reduced in acute kidney injury and administration of exogenous BMP-7 has a beneficial effect on kidney function. In spite of preventive management, contrast-induced nephropathy (CIN) is still the third cause of acute deterioration of kidney function in hospitalized patients. With this background in mind, we studied changes in serum BMP-7 in a group of patients with chronic kidney disease and contrast-induced nephropathy. MATERIALS AND METHODS: We enrolled 45 consecutive adult patients with a baseline serum creatinine ≥ 1.4 mg/dl admitted for coronary angiography. We measured serum BMP-7 levels before and 48 h after coronary angiography. The primary end point was the development of CIN, defined as an increase in serum creatinine concentration by 0.25 mg/dl or 25% over the baseline value within 72 h from contrast exposure. RESULTS: Overall, CIN occurred in 8 (17%) patients. The concentrations of serum BMP-7 were significantly decreased in the CIN group compared to baseline (488.6 ± 56.8 vs. 356.4 ± 24.8, P = 0.01); in contrast, the concentration of BMP-7 level did not change in patients without CIN (444.6 ± 54.6 vs. 440.0 ± 53.9, P = 0.09). CONCLUSION:BMP-7 level significantly decreases in patients who develop CIN after coronary angiography. Therefore, BMP-7 might be a diagnostic biomarker for CIN and a possibly promising agent for the treatment of CIN.
Authors: K A Hruska; G Guo; M Wozniak; D Martin; S Miller; H Liapis; K Loveday; S Klahr; T K Sampath; J Morrissey Journal: Am J Physiol Renal Physiol Date: 2000-07
Authors: S Vukicevic; V Basic; D Rogic; N Basic; M S Shih; A Shepard; D Jin; B Dattatreyamurty; W Jones; H Dorai; S Ryan; D Griffiths; J Maliakal; M Jelic; M Pastorcic; A Stavljenic; T K Sampath Journal: J Clin Invest Date: 1998-07-01 Impact factor: 14.808