OBJECTIVES: T2' values reflect the presence of deoxyhaemoglobin related to high local oxygen extraction. We assessed the feasibility of T2' imaging to display regions with high metabolic activity in brain gliomas. METHODS: MRI was performed in 25 patients (12 female; median age 46 years; range 2-69) with brain gliomas with additional T2 and T2* sequences. T2' maps were derived from T2 and T2*. Dynamic susceptibility weighted contrast (DSC) perfusion was performed in 12/25 patients. Images were visually assessed by two readers and five ROIs were evaluated for each patient. Pearson correlation, Mann-Whitney and Kruskal-Wallis tests were applied for statistical analysis. RESULTS: Three patients were not further evaluated because of artefacts. Mean values of high-grade (III-IV) gliomas showed significantly lower T2' values than low-grade (II) gliomas (p < 0.001). An inverse relationship was observed between rCBV and sqr (T2') (r = -0.463, p < 0.001). No correlation was observed between T2' and rCBV for grade II tumours (r = 0.038; p = 0.875). CONCLUSIONS: High-grade tumours revealed lower T2' values, presumably because of higher oxygen consumption in proliferating tissue. Our results indicate that T2' imaging can be used as an alternative to DSC perfusion in the detection of subtle deviations in tumour metabolism.
OBJECTIVES: T2' values reflect the presence of deoxyhaemoglobin related to high local oxygen extraction. We assessed the feasibility of T2' imaging to display regions with high metabolic activity in brain gliomas. METHODS: MRI was performed in 25 patients (12 female; median age 46 years; range 2-69) with brain gliomas with additional T2 and T2* sequences. T2' maps were derived from T2 and T2*. Dynamic susceptibility weighted contrast (DSC) perfusion was performed in 12/25 patients. Images were visually assessed by two readers and five ROIs were evaluated for each patient. Pearson correlation, Mann-Whitney and Kruskal-Wallis tests were applied for statistical analysis. RESULTS: Three patients were not further evaluated because of artefacts. Mean values of high-grade (III-IV) gliomas showed significantly lower T2' values than low-grade (II) gliomas (p < 0.001). An inverse relationship was observed between rCBV and sqr (T2') (r = -0.463, p < 0.001). No correlation was observed between T2' and rCBV for grade II tumours (r = 0.038; p = 0.875). CONCLUSIONS: High-grade tumours revealed lower T2' values, presumably because of higher oxygen consumption in proliferating tissue. Our results indicate that T2' imaging can be used as an alternative to DSC perfusion in the detection of subtle deviations in tumour metabolism.
Authors: Soonmee Cha; Edmond A Knopp; Glyn Johnson; Stephan G Wetzel; Andrew W Litt; David Zagzag Journal: Radiology Date: 2002-04 Impact factor: 11.105
Authors: R A Prayson; D P Agamanolis; M L Cohen; M L Estes; B K Kleinschmidt-DeMasters; F Abdul-Karim; S P McClure; B A Sebek; R Vinay Journal: J Neurol Sci Date: 2000-04-01 Impact factor: 3.181
Authors: Benjamin S Geisler; Frank Brandhoff; Jens Fiehler; Christian Saager; Oliver Speck; Joachim Röther; Hermann Zeumer; Thomas Kucinski Journal: Stroke Date: 2006-06-01 Impact factor: 7.914
Authors: T Kato; J Shinoda; N Oka; K Miwa; N Nakayama; H Yano; T Maruyama; Y Muragaki; T Iwama Journal: AJNR Am J Neuroradiol Date: 2008-08-07 Impact factor: 3.825
Authors: Rajan Jain; Lisa M Scarpace; Shehanaz Ellika; Roy Torcuator; Lonni R Schultz; David Hearshen; Tom Mikkelsen Journal: J Neurooncol Date: 2009-10-27 Impact factor: 4.130
Authors: Elke Hattingen; Alina Jurcoane; Keivan Daneshvar; Ulrich Pilatus; Michel Mittelbronn; Joachim P Steinbach; Oliver Bähr Journal: Neuro Oncol Date: 2013-08-07 Impact factor: 12.300
Authors: Max-Ludwig Schäfer; Martin H Maurer; Michael Synowitz; Joost Wüstefeld; Tim Marnitz; Florian Streitparth; Edzard Wiener Journal: Eur Radiol Date: 2013-05-19 Impact factor: 5.315
Authors: Ida Blystad; J B Marcel Warntjes; Örjan Smedby; Peter Lundberg; Elna-Marie Larsson; Anders Tisell Journal: PLoS One Date: 2017-05-23 Impact factor: 3.240