Literature DB >> 2106886

Synthetic analogs of growth hormone-releasing factor with antagonistic activity in vitro.

K Sato1, M Hotta, J Kageyama, H Y Hu, M H Dong, N Ling.   

Abstract

Analogs of human and rat growth hormone-releasing factor (hGRF and rGRF), related to [D-Arg2]hGRF(1-29)NH2, were synthesized by solid phase methodology. Their capacity to inhibit growth hormone secretion stimulated by hGRF(1-44)NH2 was tested on rat anterior pituitary cells in monolayer culture. Among the analogs of hGRF, [D-Arg2,29,Arg30]hGRF(1-30)NH2 showed the highest antagonistic potency of 3.64 relative to [D-Arg2]hGRF(1-29)NH2 = 1. However, the most potent analog synthesized thus far was [N-Ac-His1,D-Arg2,Ala15]rGRF(1-29)NH2, which showed a relative potency of 27.7.

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Year:  1990        PMID： 2106886     DOI： 10.1016/0006-291x(90)91773-l

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Antagonistic actions of analogs related to growth hormone-releasing hormone (GHRH) on receptors for GHRH and vasoactive intestinal peptide on rat pituitary and pineal cells in vitro.

Authors:  Z Rekasi; J L Varga; A V Schally; G Halmos; K Groot; T Czompoly
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

2.  Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.

Authors:  J L Varga; A V Schally; V J Csernus; M Zarándi; G Halmos; K Groot; Z Rékási
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205

3.  A method for evaluation of activity of antagonistic analogs of growth hormone-releasing hormone in a superfusion system.

Authors:  Z Rekasi; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

4.  Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone.

Authors:  M Zarandi; J E Horvath; G Halmos; J Pinski; A Nagy; K Groot; Z Rekasi; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-06       Impact factor: 11.205

5.  Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10.

Authors:  Jozsef L Varga; Andrew V Schally; Judit E Horvath; Magdolna Kovacs; Gabor Halmos; Kate Groot; Gabor L Toller; Zoltan Rekasi; Marta Zarandi
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-30       Impact factor: 11.205

6.  Antagonist of Growth Hormone-Releasing Hormone Potentiates the Antitumor Effect of Pemetrexed and Cisplatin in Pleural Mesothelioma.

Authors:  Iacopo Gesmundo; Francesca Pedrolli; Nicoletta Vitale; Alessia Bertoldo; Giulia Orlando; Dana Banfi; Giuseppina Granato; Ramesh Kasarla; Federico Balzola; Silvia Deaglio; Renzhi Cai; Wei Sha; Mauro Papotti; Ezio Ghigo; Andrew V Schally; Riccarda Granata
Journal:  Int J Mol Sci       Date:  2022-09-24       Impact factor: 6.208
  6 in total

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