| Literature DB >> 21067899 |
T Toffanin1, F Nifosì, H Follador, A Passamani, F Zonta, G Ferri, M Scanarini, P Amistà, G Pigato, C Scaroni, F Mantero, C Carollo, G I Perini.
Abstract
Several preclinical studies have demonstrated neuronal effects of glucocorticoids on the hippocampus (HC), a limbic structure with anterior-posterior anatomical and functional segmentation. We propose a volumetric magnetic resonance imaging analysis of hippocampus head (HH), body (HB) and tail (HT) using Cushing's disease (CD) as model, to investigate whether there is a differential sensitivity to glucocorticoid neuronal damage in these segments. We found a significant difference in the HH bilaterally after 12 months from trans-sphenoidal surgical selective resection of the adrenocorticotropic hormone (ACTH)-secreting pituitary micro-adenomas. This pre-post surgery difference could contribute to better understand the pathopysiology of CD as an in vivo model for stress-related hypercortisolemic neuropsychiatric disorders. Copyright ÂEntities:
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Year: 2010 PMID： 21067899 DOI： 10.1016/j.eurpsy.2010.09.003
Source DB: PubMed Journal: Eur Psychiatry ISSN： 0924-9338 Impact factor: 5.361