Su-Fang Shen1, Cai-Hong Hua. 1. Department of Obstetrics and Gynecology, the Third Hospital Affiliated to Xinxiang Medical College, Xinxiang 453103, Henan Province, China. shensufang@xxmu.edu.cn
Abstract
OBJECTIVE: To investigate the effect of l-arginine on fetal growth restriction (FGR) in terms of the expression of Bcl-2 and Bax in placenta. METHODS:Sixty pregnant women with FGR were randomized to receive conventional treatment alone (control group, n = 30) or in combination with L-arginine (L-arginine group, n = 30). The parameters of fetal growth and development were monitored by B-ultrasound at regular intervals. The newborn birth weight and perinatal outcomes were also documented. Placental tissue was sampled within 10 min after delivery for analysis. The expression of Bcl-2 and Bax in placental tissue was determined by immunohistochemical technique. RESULTS: The fetal growth parameters of biparietal diameter, femur length, and abdominal circumference increased more significantly in L-arginine group than those in control group (p < 0.01). The cure rate and birth weight in L-arginine group were higher than those in control group (73.3% vs. 43.3%, 2455.20 g vs. 2402.63 g, respectively). The incidence of small for gestational age newborns in l-arginine group was significantly lower than that in control group. Compared with L-arginine group, the Bax expression increased, but bcl-2 expression decreased in control group. CONCLUSIONS:L-arginine could reduce the expression of Bax, and enhance the expression of bcl-2, which may be associated with reduced placental apoptosis and improved placental function and fetal development.
RCT Entities:
OBJECTIVE: To investigate the effect of l-arginine on fetal growth restriction (FGR) in terms of the expression of Bcl-2 and Bax in placenta. METHODS: Sixty pregnant women with FGR were randomized to receive conventional treatment alone (control group, n = 30) or in combination with L-arginine (L-arginine group, n = 30). The parameters of fetal growth and development were monitored by B-ultrasound at regular intervals. The newborn birth weight and perinatal outcomes were also documented. Placental tissue was sampled within 10 min after delivery for analysis. The expression of Bcl-2 and Bax in placental tissue was determined by immunohistochemical technique. RESULTS: The fetal growth parameters of biparietal diameter, femur length, and abdominal circumference increased more significantly in L-arginine group than those in control group (p < 0.01). The cure rate and birth weight in L-arginine group were higher than those in control group (73.3% vs. 43.3%, 2455.20 g vs. 2402.63 g, respectively). The incidence of small for gestational age newborns in l-arginine group was significantly lower than that in control group. Compared with L-arginine group, the Bax expression increased, but bcl-2 expression decreased in control group. CONCLUSIONS:L-arginine could reduce the expression of Bax, and enhance the expression of bcl-2, which may be associated with reduced placental apoptosis and improved placental function and fetal development.
Authors: Louiza Belkacemi; Mina Desai; D Michael Nelson; Michael G Ross Journal: Am J Physiol Regul Integr Comp Physiol Date: 2011-09-14 Impact factor: 3.619
Authors: Carl R Dahlen; Pawel P Borowicz; Alison K Ward; Joel S Caton; Marta Czernik; Luca Palazzese; Pasqualino Loi; Lawrence P Reynolds Journal: Int J Mol Sci Date: 2021-10-28 Impact factor: 5.923