Literature DB >> 2106676

Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats.

E J van Hoogdalem1, C D Heijligers-Feijen, J C Verhoef, A G de Boer, D D Breimer.   

Abstract

The bile salt derivative sodium tauro-24,25-dihydrofusidate (STDHF) has been reported to promote nasal absorption of insulin. In the present study the effect of STDHF on rectal insulin absorption was investigated in rats. At concentrations of 1 and 4% (w/v) it enhanced insulin bioavailability from 0.2 +/- 0.2 (control) to 4.2 +/- 3.2 and 6.7 +/- 2.1%, respectively, as assessed by radioimmunoassay. Insulin preparations with STDHF reduced blood glucose concentrations considerably in a concentration-dependent way. Coadministration of STDHF with Na2EDTA (0.25%, w/v) tended to increase further insulin bioavailability and hypoglycemic response. Varying the site of rectal administration did not influence these parameters.

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Year:  1990        PMID： 2106676     DOI： 10.1023/a:1015837004307

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  16 in total

Review 1.  Intestinal drug absorption enhancement: an overview.

Authors:  E J van Hoogdalem; A G de Boer; D D Breimer
Journal:  Pharmacol Ther       Date:  1989       Impact factor: 12.310

2.  Site dependence of absorption-promoting actions of laureth-9, Na salicylate, Na2EDTA, and aprotinin on rectal, nasal, and buccal insulin delivery.

Authors:  B J Aungst; N J Rogers
Journal:  Pharm Res       Date:  1988-05       Impact factor: 4.200

3.  Comparison of nasal, rectal, buccal, sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption promoter.

Authors:  B J Aungst; N J Rogers; E Shefter
Journal:  J Pharmacol Exp Ther       Date:  1988-01       Impact factor: 4.030

Review 4.  Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays.

Authors:  D Rodbard
Journal:  Clin Chem       Date:  1974-10       Impact factor: 8.327

5.  Preprandial intranasal insulin.

Authors:  V Lassmann-Vague; D Thiers; B Vialettes; P Vague
Journal:  Lancet       Date:  1988-02-13       Impact factor: 79.321

6.  Human insulin plus sodium glycocholate in a nasal spray formulation: improved bioavailability and effectiveness in normal subjects.

Authors:  A E Pontiroli; M Alberetto; E Pajetta; A Calderara; G Pozza
Journal:  Diabete Metab       Date:  1987 Jul-Aug

7.  Avoidance of "first-pass" elimination of rectally administered lidocaine in relation to the site of absorption in rats.

Authors:  L G de Leede; A G de Boer; C P Roozen; D D Breimer
Journal:  J Pharmacol Exp Ther       Date:  1983-04       Impact factor: 4.030

8.  Insulin administered intranasally as an insulin-bile salt aerosol. Effectiveness and reproducibility in normal and diabetic subjects.

Authors:  A C Moses; G S Gordon; M C Carey; J S Flier
Journal:  Diabetes       Date:  1983-11       Impact factor: 9.461

9.  Enteral administration of insulin in the rat.

Authors:  H Bar-On; E M Berry; A Eldor; M Kidron; D Lichtenberg; E Ziv
Journal:  Br J Pharmacol       Date:  1981-05       Impact factor: 8.739

Review 10.  Rectal administration of insulin.

Authors:  W A Ritschel; G B Ritschel
Journal:  Methods Find Exp Clin Pharmacol       Date:  1984-09
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  2 in total

1.  Permeation enhancement of octreotide by specific bile salts in rats and human subjects: in vitro, in vivo correlations.

Authors:  G Fricker; A Fahr; C Beglinger; T Kissel; G Reiter; J Drewe
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

2.  Effects of deoxycholate on the transepithelial transport of sucrose and horseradish peroxidase in filter-grown Madin-Darby canine kidney (MDCK) cells.

Authors:  Y J Lin; W C Shen
Journal:  Pharm Res       Date:  1991-04       Impact factor: 4.200
  2 in total

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