Literature DB >> 2106569

DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.

T Blankenstein1, Z H Qin, W Q Li, T Diamantstein.   

Abstract

To study the potential involvement of IL-6 in the development of plasmacytomas, a number of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement due to the insertion of an intracisternal A particle retrotransposon 18 bp 5' of the transcriptional start site was detected in the cell line MPC11. The IL-6 gene is constitutively expressed in MPC11, suggesting the involvement of IL-6 in the development of certain myeloma/plasmacytomas according to the "autocrine growth hypothesis".

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Year:  1990        PMID： 2106569      PMCID： PMC2187786          DOI： 10.1084/jem.171.3.965

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  17 in total

1.  Structure and evolution of mouse interleukin 6 gene.

Authors:  Z Qin; G Richter; T Diamantstein; T Blankenstein
Journal:  Mol Immunol       Date:  1989-11       Impact factor: 4.407

2.  Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6.

Authors:  B Klein; X G Zhang; M Jourdan; J Content; F Houssiau; L Aarden; M Piechaczyk; R Bataille
Journal:  Blood       Date:  1989-02       Impact factor: 22.113

3.  cDNA cloning of murine interleukin-HP1: homology with human interleukin 6.

Authors:  J Van Snick; S Cayphas; J P Szikora; J C Renauld; E Van Roost; T Boon; R J Simpson
Journal:  Eur J Immunol       Date:  1988-02       Impact factor: 5.532

Review 4.  Molecular regulation of B lymphocyte response.

Authors:  T Kishimoto; T Hirano
Journal:  Annu Rev Immunol       Date:  1988       Impact factor: 28.527

5.  Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas.

Authors:  J B Cohen; T Unger; G Rechavi; E Canaani; D Givol
Journal:  Nature       Date:  1983 Dec 22-1984 Jan 4       Impact factor: 49.962

Review 6.  Autocrine growth factors and cancer.

Authors:  M B Sporn; A B Roberts
Journal:  Nature       Date:  1985 Feb 28-Mar 6       Impact factor: 49.962

7.  Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.

Authors:  F Sanger; A R Coulson; B G Barrell; A J Smith; B A Roe
Journal:  J Mol Biol       Date:  1980-10-25       Impact factor: 5.469

Review 8.  Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men.

Authors:  G Klein
Journal:  Cell       Date:  1983-02       Impact factor: 41.582

9.  Products of a reciprocal chromosome translocation involving the c-myc gene in a murine plasmacytoma.

Authors:  L W Stanton; J Q Yang; L A Eckhardt; L J Harris; B K Birshtein; K B Marcu
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

10.  Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. I. Adaptation of the Merwin plasma cell tumor-11 to culture, cloning, and characterization of gamma globulin subunits.

Authors:  R Laskov; M D Scharff
Journal:  J Exp Med       Date:  1970-03-01       Impact factor: 14.307
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  14 in total

1.  Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B cell lymphoma.

Authors:  C E Malstrom; A L Kotsenas; B Jones
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

2.  Co-amplification to tail-to-tail copies of MuRVY and IAPE retroviral genomes on the Mus musculus Y chromosome.

Authors:  J Fennelly; K Harper; S Laval; E Wright; M Plumb
Journal:  Mamm Genome       Date:  1996-01       Impact factor: 2.957

3.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1990-05-25       Impact factor: 16.971

4.  Intracisternal A-type particle-mediated activations of cytokine genes in a murine myelomonocytic leukemia: generation of functional cytokine mRNAs by retroviral splicing events.

Authors:  K B Leslie; F Lee; J W Schrader
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272

5.  Cyclosporin A promotes translational silencing of autocrine interleukin-3 via ribosome-associated deadenylation.

Authors:  A P Nair; H H Hirsch; M Colombi; C Moroni
Journal:  Mol Cell Biol       Date:  1999-01       Impact factor: 4.272

6.  The interleukin-6 gene locus seems to be a preferred target site for retrotransposon integration.

Authors:  Z H Qin; I Schuller; G Richter; T Diamantstein; T Blankenstein
Journal:  Immunogenetics       Date:  1991       Impact factor: 2.846

7.  The intracisternal A particle derived solo LTR promoter of the rat oncomodulin gene is not present in the mouse gene.

Authors:  D Banville; M Rotaru; Y Boie
Journal:  Genetica       Date:  1992       Impact factor: 1.082

8.  Suppression of in vivo tumor growth by the transfection of the interleukin-5 gene into colon tumor cells.

Authors:  Y Masuda; S Mita; K Sakamoto; T Ishiko; M Ogawa
Journal:  Cancer Immunol Immunother       Date:  1995-12       Impact factor: 6.968

9.  Activation of the mouse mdr3 gene by insertion of retroviruses in multidrug-resistant P388 tumor cells.

Authors:  P Lepage; A Devault; P Gros
Journal:  Mol Cell Biol       Date:  1993-12       Impact factor: 4.272

10.  Identification of a novel posttranscriptional regulatory element by using a rev- and RRE-mutated human immunodeficiency virus type 1 DNA proviral clone as a molecular trap.

Authors:  F Nappi; R Schneider; A Zolotukhin; S Smulevitch; D Michalowski; J Bear; B K Felber; G N Pavlakis
Journal:  J Virol       Date:  2001-05       Impact factor: 6.549
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